Complement Factor I Antibody (3R/8)

native human factor I from serum

NB100-64814 recognizes complement factor I, a member of the peptidase S1 family present in the blood plasma. Factor I is an 88 kDa protein consisting of one polypeptide chain of 35.4 kDa and one of 27.6 kDa. Factor I is a serine protease which inactivates complement components C3b and C4b. C3b cleavage requires the presence of cofactors complement component (3b/4b) receptor 1 (CR1), membrane cofactor protein or factor H, while C4b cleavage requires complement component 4 binding protein or CR1. Factor I has no natural inhibitors. Dysfunctional factor I can lead to uncontrolled activation of the alternative complement pathway causing in systemic depletion of C3 and lower levels of factors B and H, resulting in recurrent pyogenic infections. Defects in CFI are also associated with haemolytic uraemic syndrome. NB100-64814 blocks function of complement factor I. Removal of Sodium Azide is recommended prior to use in functional assays.

IgG1

Monoclonal

Mouse

CFI

Protein A or G purified

Test in a species/application not listed above to receive a full credit towards a future purchase.