FUS Antibody 0.025 ml

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Western Blot: FUS Antibody [NBP1-50623] - Analysis of FUS in HeLa nuclear extracts.
Immunocytochemistry/Immunofluorescence: FUS Antibody [NBP1-50623] - Staining of FUS in HeLa cells with  FITC (green). Nuclei were counterstained with DAPI (blue).
Immunohistochemistry: FUS Antibody [NBP1-50623] - Staining of FUS in human renal cell carcinoma.
Western Blot: FUS Antibody [NBP1-50623] - Analysis of FUS in Jurkat nuclear extracts.
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Ordering Information: NBP1-50623

  • Catalog Number
    NBP1-50623
  • Displayed Format
    Unconjugated
  • Other Formats
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FUS Antibody Summary

Species Human, Mouse
Predicted Species
Bovine (91%). Backed by our 100% Guarantee
Tested Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Gene
FUS
Purity
Immunogen affinity purified
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FUS Antibody Details

Immunogen
A genomic peptide made to an N-terminal region of the human FUS protein (within residues 1-150). [Swiss-Prot P35637]
Localization
Nucleus

Species Reactivity

Human and Mouse. Immunogen sequence has 91% identity to bovine.
Publications Read Publications using NBP1-50623 in the following species:


Applications/Dilutions

Dilutions
  • Western Blot 1:5000
  • Immunocytochemistry/Immunofluorescence 1:150
  • Immunohistochemistry 1:250
  • Immunohistochemistry-Paraffin 1:250
Application Notes
This FUS antibody is useful for IHC, ICC/IF and WB where a doublet is seen ~70 kDa. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Positive Controls
Other Available
Formats
Alexa Fluor (R) 405 Labeled NBP1-50623AF405
Alexa Fluor (R) 488 Labeled NBP1-50623AF488
Alexa Fluor (R) 647 Labeled NBP1-50623AF647
Alexa Fluor (R) 700 Labeled NBP1-50623AF700
Biotin Labeled NBP1-50623B
DyLight 488 Labeled NBP1-50623G
DyLight 550 Labeled NBP1-50623R
DyLight 650 Labeled NBP1-50623C
HRP Labeled NBP1-50623H
Publications
Read Publications using
NBP1-50623 in the following applications:

Contact Information

Product PDFs

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Reviews

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Publications

FUS Antibody (NBP1-50623) has been mentioned in at least 2 publications.
Earn rewards if you have published using FUS Antibody (NBP1-50623).

Notes

Manufactured by Genomic Antibody Technology™. GAT FAQs

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, 0.1% BSA, 30% glycerol
Unit Size
0.025 ml
Concentration
1.3 mg/ml
Preservative
0.05% Sodium Azide
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

Gene Symbol FUS
Entrez
Uniprot

Alternate Names for FUS Antibody

  • 75 kDa DNA-pairing protein
  • ALS6
  • amyotrophic lateral sclerosis 6
  • FUS1
  • fused in sarcoma
  • fusion (involved in t(12;16) in malignant liposarcoma)
  • fusion gene in myxoid liposarcoma
  • fusion, derived from t(12;16) malignant liposarcoma
  • fus-like protein
  • heterogeneous nuclear ribonucleoprotein P2
  • HNRNPP2
  • Oncogene FUS
  • Oncogene TLS
  • POMP75
  • POMp75
  • RNA-binding protein FUS
  • TLShnRNP-P2
  • Translocated in liposarcoma protein
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Related Products by Gene

Background

The protein originally described as fused in Sarcoma is actually related to a number of different cellular processes and correlated to several diseases. FUS binds DNA as a single or double strand, and acts as a site for transcription factors to recognize. Since FUS is well-documented to be involved in liposarcoma, lipoma and leukaemia, it is believed that when its normal housekeeping functions related to transcription are disrupted, normal cells become cancerous. Interestingly, FUS is also associated with the fatal neuron disorder amyotrophic lateral sclerosis; interruption of its normal RNA-binding functions leads to incorrect cellular localization and leads to pathologies of the neuron. Thus, FUS regulation of cellular functions is a critical component of maintenance of healthy cells.

Reviews for FUS Antibody (NBP1-50623) (0)

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Publications for FUS Antibody (NBP1-50623) (2)

Read what people are writing who have used FUS Antibody (NBP1-50623).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: WB, IHC-P.

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Product General Protocols

View specific protocols for FUS Antibody (NBP1-50623): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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FAQs for FUS (2)

  1. In the immunohistochemistry paraffin section protocol....the PBS buffer....should it be at certain pH?
    • For IHC application, different labs cites the pH of PBS buffer in the range of 7.1 - 7.6 but most commonly used pH is pH 7.4 (this is what we use in our lab). You may use this PBS (pH 7.4) for making permeablization buffer, antibody diluent buffers and for making wash buffer. For more on the protocol that we use in our lab and for IHC-P troubleshooting suggestions, you may visit: IHC-P Protocol and IHC-P Troubleshooting.
  2. I was wondering what does Format 7C mean as far as anitbodies go?
    • 7C is a fluorophore - it is useful for FLOW. The details of the fluor are (A=425, E=500)

Bioinformatics Tool for FUS

Discover related pathways, diseases and genes to FUS. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Bioinformatics Tool

Research Areas for FUS

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Blogs on FUS

Check out the latest blog posts on FUS.
Amyotrophic Lateral Sclerosis Infographic
Amyotrophic lateral sclerosis is a neurological disease which impacts motor neurons that are involved in muscle movement throughout the body. The progressive degeneration of neurons causes weakened muscles and can lead to paralysis. There is no cure f...  Read full blog post.