FOXO3 Antibody (EP1949Y)

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Forkhead box O-class (FOXO) transcription factors are mammalian homologue of DAF-16, a known lifespan regulator of Caenorhabditis elegans. FOXO transcription factors, such as FOXO1, FOXO3a, and FOXO4, have been linked to the regulation of cell cycle, apoptosis, DNA repair, oxidative stress, and metabolism (1). FOXO proteins are proposed to be dual regulated by Akt-mediated phosphorylation and Skp2-mediated ubiquitination, which are usually initiated by growth factors and cytokines. FOXO proteins are also activated by stress, which induces gene expression that contributes to cell cycle arrest, implicating FOXO proteins as tumor suppressors (2). Specifically, FOXO3a (FKHR-L1) is a transcriptional activator for apoptosis in the absence of survival factors, such as in neural cell death triggered by oxidative stress. In the presence of survival factors like IGF-1, AKT1/PKB phosphorylates on Thr-32 and Ser-253. However, in the absence of survival factors, FOXO3a is dephospholyated and translocated to the nucleus inducing transcription of target genes and apoptosis (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NB110-56994	Applications	Species
Poulsen RC, Carr AJ, Hulley PA. Protection against glucocorticoid-induced damage in human tenocytes by modulation of ERK, Akt, and forkhead signaling Endocrinology 2011-01-07 [PMID: 21209015] Details: Citation using the Non-Recombinant Monoclonal format of this antibody.
Shiota M, Yokomizo A, Kashiwagi E et al. Foxo3a expression and acetylation regulate cancer cell growth and sensitivity to cisplatin. Cancer Sci 2010-05-01 [PMID: 20210796] (WB)	WB

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	WB	Human	12/12/2011	View Summary Application Western Blot Sample Tested Human Species Human

Array NB110-56994

• FOXO3 Antibodies
• FOXO3 ELISA Kits
• FOXO3 Lysates
• FOXO3 Proteins