FADD Antibody

Fas-associating protein with death domain (FADD) is an adaptor protein involved in the apoptosis induced by Fas and TNF-R1, and mitogen induced cell proliferation (1). FADD consists of death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to inactivation of Fas-FADD interaction (4). Also, the deficiency in FADD can inhibit TRAIL-induced cell apoptosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 2 of 2.

Publications using NB100-92032	Applications	Species
Ranjan K, Pathak C. FADD regulates NF-kB activation and promotes ubiquitination of cFLIPL to induce apoptosis. Sci Rep. 2016-03-14 [PMID: 26972597] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Ranjan K, Surolia A, Pathak C. Apoptotic potential of Fas-associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells. J Cell Commun Signal. 2012-08-01 [PMID: 22791313] (WB, Human)	WB	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Kishu Ranjan	WB	Human	01/31/2014	View Summary Application Western Blot Species Human

Array NB100-92032

• FADD Antibodies
• FADD Lysate
• FADD Proteins