ErbB2/HER2 Antibody (NB110-56964)

ErbB2/HER2 Antibody (NB110-56964) ( 0.1 ml)

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	Catalog Number	NB110-56964
	Size(s)	0.1 ml	Price: N/A
	Availability	Discontinued
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anti-MLN 19 antibody, anti-EC 2.7.10 antibody, anti-Tyrosine kinase-type cell surface receptor HER2 antibody, anti-CD340 antigen antibody, anti-Proto-oncogene Neu antibody, anti-MLN19 antibody, anti-Proto-oncogene c-ErbB-2 antibody, anti-receptor tyrosine-protein kinase erbB-2 antibody, anti-Metastatic lymph node gene 19 protein antibody, anti-neuroblastoma/glioblastoma derived oncogene homolog antibody, anti-v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog) antibody, anti-herstatin antibody, anti-HER-2 antibody, anti-c-erb B2/neu protein antibody, anti-CD340 antibody, anti-NGLTKR1 antibody, anti-NEUHER-2/neu antibody, anti-HER2EC 2.7.10.1 antibody, anti-p185erbB2 antibody, anti-v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian) antibody

ErbB2/HER2 Antibody Summary:

Species:	Hu, Mu, Rt	Gene:	ERBB2
Applications:	WB, FACS, IHC-P, IP	Purity:	IgG purified
Clonality:	Monoclonal	Host:	Rabbit
Specificity:	This antibody detects Her2 phosphorylated at Tyr1248 as well as unphosphorlyated Her2.
Publications:

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ErbB2/HER2 Antibody Details:

Immunogen:	A synthetic peptide corresponding to residues near the C-terminus of human Her2 was used as an immunogen.

Species Reactivity:

Human

Applications:

Uses:	This antibody is useful for flow cytometry / FACS analysis, Immunohistochemistry-Paraffin, immunoprecipitation and Western Blot
Dilutions:	Flow Cytometry 1:30, Immunohistochemistry-Paraffin, Immunoprecipitation 1:50, Western Blot 1:50000 – 100000
Unit Size:	0.1 ml
Concentration:	Please see the vial label for concentration.

Packaging:

Storage:	Store at -20°C. Avoid freeze-thaw cycles.
Preservative:	0.01% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: ERBB2

Related Genes:

Background:

ErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.

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ErbB2/HER2 Antibody Images (3)

	Western Blot: ErbB2/Her2 Antibody (EP1045Y) [NB110-56964] - Western blot analysis on SKBR-3 cell lysate using anti-ErbB2/Her2 (cat. # 110-56964), dilution 1:100,000.

	Immunohistochemistry: ErbB2/Her2 Antibody (EP1045Y) [NB110-56964] - Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-ErbB2/Her2 (cat. #110-56964).