ErbB2/HER2 Antibody (S-495) (NBP1-72166)

ErbB2/HER2 Antibody (S-495) (NBP1-72166) (100 ug)

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	Catalog Number	NBP1-72166
	Size(s)	100 ug	Price:
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anti-MLN 19 antibody, anti-EC 2.7.10 antibody, anti-Tyrosine kinase-type cell surface receptor HER2 antibody, anti-CD340 antigen antibody, anti-Proto-oncogene Neu antibody, anti-MLN19 antibody, anti-Proto-oncogene c-ErbB-2 antibody, anti-receptor tyrosine-protein kinase erbB-2 antibody, anti-Metastatic lymph node gene 19 protein antibody, anti-neuroblastoma/glioblastoma derived oncogene homolog antibody, anti-v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog) antibody, anti-herstatin antibody, anti-HER-2 antibody, anti-c-erb B2/neu protein antibody, anti-CD340 antibody, anti-NGLTKR1 antibody, anti-NEUHER-2/neu antibody, anti-HER2EC 2.7.10.1 antibody, anti-p185erbB2 antibody, anti-v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian) antibody

ErbB2/HER2 Antibody (S-495) Summary:

Species:	Hu, Mu, Rt	Gene:	ERBB2
Applications:	WB, ELISA, FACS, IHC, IP	Purity:	Affinity purified
Clonality:	Monoclonal	Host:	Mouse
Specificity:	This antibody recognizes ErbB2/HER2 protein. It cross-reacts with human, rat and mouse. The other species was not tested.
Publications:	NBP1-72166 has been mentioned in at least 1 Publication

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ErbB2/HER2 Antibody (S-495) Details:

Clone:	S-495
Immunogen:	A synthetic peptide corresponding to the C-terminus of ErbB2/HER2 protein.

Species Reactivity:

Reactive in Human, Mouse, and Rat

Applications:

Uses:	Useful in Western Blot, ELISA, Immunoprecipitation, IHC, and Flow Cytometry
Dilutions:	ELISA 0.01-0.1 ug/ml, Flow Cytometry 5-10 ug/ml, Immunohistochemistry 2-5 ug/ml, Immunoprecipitation 2-5 ug/ml, Western Blot 0.1 - 1 ug/ml
Unit Size:	100 ug
Concentration:	Please see the vial label for concentration.
Positive Controls:	1 Positive Controls

Notes:

WB Caption - The whole cell lysates from SK-BR-3 were resolved onto 10% SDS-PAGE, transferred onto NC membrane, and followed by an Immunoblotting with Mouse anti Her-2 antibody at 1:500. An immunoreactive band is observed around ~185 kDa.

Packaging:

Storage:	Store at 4°C short term. Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Buffer:	This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
Preservative:	No Preservative
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: ERBB2

Related Genes:

Background:

Oncoprotein Her-2/Neu/ c-erbB-2 belongs to one of the four members of the ErbB receptor family. They are transmembrane receptor-like tyrosine kinases which can be autophosphorylated without ligand binding process when it is overexpressed in breast cancers. Her2 is an important biomarker in breast cancer diagnosis. The antibodies/ heregulin can suppress phosphorylation of HER2 on tyrosine Y1248. Endogenous anti-HER2 antibodies can effectively suppress HER2 kinase activity and downstream signaling to inhibit the transformed phenotype of HER2-expressing tumor cells. Thus, anti-Her2 antibodies have been used widely in the treatment of the breast cancer and other carcinomas.

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