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ErbB 2 Antibody (NB110-56964)

ErbB 2 Antibody

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ErbB 2 Antibody Summary:
Species:Hu, Mu, Rt
Applications:FACS, IHC-P, IP, WB
Clonality:Monoclonal
Gene:ERBB2
Purity:IgG purified
Host:Rabbit
Specificity: This antibody detects Her2 phosphorylated at Tyr1248 as well as unphosphorlyated Her2.
 
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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ErbB 2 Antibody Details:
Immunogen:A synthetic peptide corresponding to residues near the C-terminus of human Her2 was used as an immunogen.
Species Reactivity:

Human

Applications:
Uses:This antibody is useful for flow cytometry / FACS analysis, Immunohistochemistry-Paraffin, immunoprecipitation and Western Blot
Dilutions:Flow Cytometry 1:30, Immunohistochemistry-Paraffin, Immunoprecipitation 1:50, Western Blot 1:50000 – 100000
Unit Size: 0.1 ml
Concentration:Please see the vial label for concentration.
Packaging:
Storage:Store at -20 °C. Avoid freeze-thaw cycles.
Preservative:0.01% Sodium Azide
Limitations:This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Gene Symbol: ERBB2
 
Background:

ErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.

 
Images (3)
  • Immunohistochemistry: ErbB2/Her2 Antibody (EP1045Y) [NB110-56964] - Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-ErbB2/Her2 (cat. #110-56964).
  • Western Blot: ErbB2/Her2 Antibody (EP1045Y) [NB110-56964] - Western blot analysis on SKBR-3 cell lysate using anti-ErbB2/Her2 (cat. # 110-56964), dilution 1:100,000.

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ErbB 2 Antibody Images (3)
Immunohistochemistry: ErbB2/Her2 Antibody (EP1045Y) [NB110-56964] - Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-ErbB2/Her2 (cat. #110-56964).Western Blot: ErbB2/Her2 Antibody (EP1045Y) [NB110-56964] - Western blot analysis on SKBR-3 cell lysate using anti-ErbB2/Her2 (cat. # 110-56964), dilution 1:100,000.
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ErbB 2 in Context

Research Areas related to ErbB 2 (7):
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