Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
Synthetic peptide derived from the sequence of rat Erk 1, conjugated to KLH; sequence identical to hamster
Species Reactivity:
Human, Mouse, Rat, Bovine, Sheep, Chicken, Drosophila, Xenopus.
Applications:
Uses:
This antibody is useful for Flow cytometry, Immunohistochemistry-Paraffin, Western blot.
Dilutions:
Flow Cytometry, Immunohistochemistry-Paraffin, Western Blot
Unit Size:
0.05 mg
Concentration:
Please see the vial label for concentration.
Packaging:
Storage:
Store at -20 °C. Avoid freeze-thaw cycles.
Preservative:
Sodium Azide
Limitations:
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
ERK (extracellular signal regulated kinase), also known as MAPK (mitogen activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 are phosphorylated within the activation loop on both a Threonine and a Tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1&2.