ERK1/2 [p Thr202, p Tyr204, p Thr185, p Tyr187] Antibody (E337) (NB110-56969)

ERK1/2 [p Thr202, p Tyr204, p Thr185, p Tyr187] Antibody (E337) (NB110-56969) (0.1 ml)

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	Catalog Number	NB110-56969
	Size(s)	0.1 ml	Price:
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anti-EC 2.7.11 antibody, anti-MAPK 3 antibody, anti-extracellular signal-related kinase 1 antibody, anti-MAPK 1 antibody, anti-P44MAPK antibody, anti-MAP kinase isoform p44 antibody, anti-P44ERK1 antibody, anti-MAP kinase 3 antibody, anti-MAP kinase 1 antibody, anti-ERT2 antibody, anti-MGC20180 antibody, anti-ERK-1 antibody, anti-HUMKER1A antibody, anti-Mitogen-activated protein kinase 1 antibody, anti-HS44KDAP antibody, anti-Microtubule-associated protein 2 kinase antibody, anti-p44mapk antibody, anti-Insulin-stimulated MAP2 kinase antibody, anti-p44erk1 antibody, anti-Extracellular signal-regulated kinase 1 antibody, anti-PRKM3EC 2.7.11.24 antibody, anti-ERK1p44-MAPK antibody, anti-p44-ERK1 antibody, anti-mitogen-activated protein kinase 3 antibody

ERK1/2 [p Thr202, p Tyr204, p Thr185, p Tyr187] Antibody (E337) Summary:

Species:	Hu	Gene:	MAPK3
Applications:	WB, ICC, IHC-P	Purity:	IgG purified
Clonality:	Monoclonal	Host:	Rabbit
Specificity:	The antibody only detects Erk1 phosphorylated on Threonine 202 or Erk2 phosphorylated on Threonine 185.
Publications:	NB110-56969 has been mentioned in at least 1 Publication

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ERK1/2 [p Thr202, p Tyr204, p Thr185, p Tyr187] Antibody (E337) Details:

Clone:	E337
Isotype:	IgG
Immunogen:	A synthetic phospho-peptide corresponding to residues surrounding Thr202 of human Erk1 was used as immunogen.
Modification:	p Thr202, p Tyr204, p Thr185, p Tyr187

Species Reactivity:

Human. Cross reactivity determined by Western Blot only.

Applications:

Uses:	This product is useful for: Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry. In Western blot this antibody detects a band at approximately 42/44kDa.
Dilutions:	Western Blot 1:1000-10000, Immunohistochemistry-Paraffin 1:50, Immunocytochemistry 1:250
Unit Size:	0.1 ml
Concentration:	Please see the vial label for concentration.

Packaging:

Storage:	Store at -20°C. Avoid freeze-thaw cycles.
Buffer:	50 mM Tris-Glycine [pH 7.4] containing 0.15 M NaCl, 40% Glycerol and 0.05% BSA
Preservative:	0.01% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: MAPK3

Entrez:	5595 (Human)
	26417 (Mouse)
	50689 (Rat)
Uniprot:	P27361 (Human)

Related Genes:

Background:

Extra cellular signal-regulated kinases Erk1 (p44 MAPK) and Erk2 (p42 MAPK) Serine/Threonine proteine kinase are part of a subfamily of mitogen-activated protein kinases that participate in diverse cellular functions, including the regulation of cell growth, differentiation, apoptosis and signal transduction (1,2,3) The simultaneous tyrosine/threonine phosphorylation of ERK1 and ERK2 results in their activation. Although ERK1and ERK2 resemble one another closely in sequence and are activated by similar pathways, they appearto have different tissue distributions(4) and show differential phosphorylation of potential intracellular substrates(5)

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ERK1/2 [p Thr202, p Tyr204, p Thr185, p Tyr187] Antibody (E337) Images (2)

	Western Blot: ERK1/ERK2 phosphospecific Antibody (E337) [NB110-56969] - Western blot analysis on serum starved (ss)A431 cell lysate using anti-ERK1(pT202/pY204) /ERK2(pT185/pY187) (cat. #110-56969); dilution 1:500

	Immunohistochemistry: ERK1/ERK2 phosphospecific Antibody (E337) [NB110-56969] - Immunohistochemical analysis of paraffin-embedded human thyroid gland cancer using anti- ERK1(pT202/pY204) /ERK2(pT185/pY187)