EGF Antibody (NB100-65982)
EGF Antibody
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Distributor Data...
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anti-Beta urogastrone antibody, anti-Urogastrone antibody, anti-URG antibody, anti-Pro epidermal growth factor antibody, anti-Epidermal Growth Factor antibody, |
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EGF Antibody Summary: | | Gene: | EGF |
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| Purity: | Whole antisera |
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| Host: | Rabbit |
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| | Specificity: | Reacts with mouse EGF 100%. Low reactivity with human EGF. Confirmed by Ouchterlony double diffusion. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional EGF Products EGF Antibody Details: | Isotype: | IgG |
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| Immunogen: | Native, from submaxillaries |
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| Localization: | Cell Membrane, single-pass type I membrane protein [precursor] and Secreted [EGF]. |
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Mouse, weakly human Not yet tested in other species. |
| Uses: | This antibody is useful for Radioimmunoassays |
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| Dilutions: | Radioimmunoassay |
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| Unit Size: | 0.1 ml |
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| Concentration: | This product is unpurified. Concentration is not relevant. |
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Packaging: | Storage: | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
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| Buffer: | Without preservatives |
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| Preservative: | Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: Epidermal growth factor (EGF) has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. EGF exerts its actions by binding to the EGFR, a 170 kDa protein.
Epidermal growth factor (EGF) is a key growth factor regulating cell survival. Through its binding to cell surface receptors, EGF activates an extensive network of signal transduction pathways that include activation of the PI3K/AKT, RAS/ERK and JAK/STAT pathways. Because of its key role in driving the proliferation of cells, EGFR is a target of several anti-cancer drugs currently in development.
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Jump to: Lysates, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies
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