EGF Antibody

Species: Mu Applications: RIA Clonality: Polyclonal	Gene: EGF Purity: Whole antisera Host: Rabbit
Specificity: Reacts with mouse EGF 100%. Low reactivity with human EGF. Confirmed by Ouchterlony double diffusion.
See All EGF Products See All EGF Related Products: Kits Lysates Peptides and Proteins Primary Antibodies RNAi
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Isotype:	IgG
Immunogen:	Native, from submaxillaries
Localization:	Cell Membrane, single-pass type I membrane protein [precursor] and Secreted [EGF].

Entrez:	1950 (Human)
	13645 (Mouse)
Related Genes:	EGFR, FGF2, TGFA, INS, MAPK1, MAPK3, NUDT6, TNF, IL6, NGF, HGF, TGFB1, VEGFA, AKT1, EPHB2, JUN, HRAS1, MET, ERBB2, FOS, KRAS, SGSM3, SRC, TRF, PRKCG, TF, PTGS2, PRL, MDK, MAPK12, MYC, PCNA, AREG, FGF7, IGF2, GH, BRD2, ALB, CDKN1A, IL1B

Epidermal growth factor (EGF) has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. EGF exerts its actions by binding to the EGFR, a 170 kDa protein. Epidermal growth factor (EGF) is a key growth factor regulating cell survival. Through its binding to cell surface receptors, EGF activates an extensive network of signal transduction pathways that include activation of the PI3K/AKT, RAS/ERK and JAK/STAT pathways. Because of its key role in driving the proliferation of cells, EGFR is a target of several anti-cancer drugs currently in development.

Reactivity:	Mouse, weakly human Not yet tested in other species.

Uses:	This antibody is useful for Radioimmunoassays
Dilutions:	Radioimmunoassay

Buffer:	Without preservatives
Storage:	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Preservative:	Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.