E2F4 Antibody (2B6-G9)

Species: Hu Applications: WB, ELISA Clonality: Monoclonal	Gene: E2F4 Purity: IgG purified Host: Mouse
Specificity: E2F6 - E2F transcription factor 6
See All E2F4 Products See All E2F4 Related Products: Lysates Peptides and Proteins Primary Antibodies RNAi
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Clone:	2B6-G9
Isotype:	IgG2a Kappa
Immunogen:	E2F6 (AAH08348, 1 a.a. ~ 282 a.a) full length recombinant protein with GST tag.
Epitope:	MSQQRPARKLPSLLLDPTEETVRRRC RDPINVEGLLPSKIRINLEDNVQYVS MRKALKVKRPRFDVSLVYLTRKFMDL VRSAPGGILDLNKVATKLGVRKRRVY DITNVLDGIDLVEKKSKNHIRWIGSD LSNFGAVPQQKKLQEELSDLSAMEDA LDELIKDCAQQLFELTDDKENERLAY VTYQDIHSIQAFHEQIVIAVKAPAET RLDVPAPREDSITVHIRSTNGPIDVY LCEVEQGQTSNKRSEGVGTSS

Entrez:	1874 (Human)
Omim:	602944 (Human)
Swiss Prot:	AAH08348 (Human)
Related Genes:	E2F1, RBL2, RBL1, PLCL1, RAB3GAP1, CDH17, PPP1R9B, NOLC1, E2F5, E2F2, RB1, CDKN1A, CDK2, E2F3, MST1, TFDP1, CDKN1B, CDK4, ARID4A, PTGDR, EPHA4, CCNE1, TRP53, TP53, CCND1, KRAS, NSG1, TPT1, TCEAL1, D4S234E, CDKN2A, PCNA, MYC, DSP, SRPR, NKX3-1, BAX, PAK3, MSH3, IFI27

This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.

Reactivity:	Human. Other species not tested.

Uses:	Antibody Reactive against Recombinant Protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control.
Dilutions:	ELISA, Western Blot 1:500

This product is produced by and distributed for Abnova, a company based in Taiwan.

Storage:	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Preservative:	No Preservative
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.