This TYRO3 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band can be seen at ~96 kDa. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
TYRO3 (tyrosine-protein kinase receptor TYRO3) is a RTK which facilitate transduction of signals from extracellular matrix (ECM) into cytoplasm via its direct interaction with multiple ligands such as TUB, TULP1 or GAS6 for the regulation of multiple biological processes such as cell survival, migration and differentiation. TYRO3-ligand binding stimulates its dimerization as well as autophosphorylation on its intracellular domain that provides docking sites for the molecules of downstream signaling. Once stimulated, TYRO3 interacts with PIK3R1 leading to increased PI3K activity followed by AKT signaling activation including NFkB nuclear translocation mediated up-regulation of transcription of NFkB's target genes. TYRO3 signaling events are critical to neuron protection from excitotoxic injury, platelet aggregation, cytoskeletal reorganization, inhibition of TLRs-mediated innate immune response via STAT1 activation followed by production of cytokine signaling suppressors (SOCS1 and SOCS3). TYRO3 is highly expressed during CNS neurogenesis with distinct patterns in adult brain and has been closely related to CNS immunodysfunction.
Reviews for Dtk/TYRO3 Antibody (NBP1-28635) (0)
There are no reviews for Dtk/TYRO3 Antibody (NBP1-28635).
By submitting a review earn points towards our Rewards Program.
250 points for product review
500 additional points for an image with your product review
Double points (500) if you are the first to review this product
Double points (1000) if you are the first to review this product with an image
Have you used Dtk/TYRO3 Antibody (NBP1-28635)? Submit your review and earn rewards points which can be used for merchandise & discounts.