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Dopamine D2R/DRD2 Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB600-1261
    • Availability
      Product Discontinued

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Dopamine D2R/DRD2 Antibody Summary

Immunogen
D2 (aa272-282) covalently attached to a carrier protein.
Epitope
Specific for Dopamine D2 Receptor (a.a. 272-282).
Localization
Plasma membrane
Specificity
Cross reacts 100% with D2 dopamine receptor, 70% with D2s dopamine receptor and 60% with D2L dopamine receptor. Does not cross react with D1, D3, D4 or D5 dopamine receptors.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DRD2
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 1:5000
  • Western Blot 1:800
Application Notes
Detects two bands at ~48 kDa and ~51 kDa
Publications
Read Publication using
NB600-1261 in the following applications:

Reactivity Notes

The immunogen sequence is highly conserved across a broad range of species.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Whole antiserum diluted with PBS. 10 mg/ml BSA.
Preservative
No Preservative
Concentration
LYOPH
Purity
Unpurified
Reconstitution Instructions
Reconstitute with 100ul sterile PBS.

Alternate Names for Dopamine D2R/DRD2 Antibody

  • D(2) dopamine receptor
  • D2DR
  • D2R
  • Dopamine D2 R
  • Dopamine D2 receptor
  • Dopamine D2R
  • dopamine receptor D2 isoform
  • dopamine receptor D2
  • DRD2
  • seven transmembrane helix receptor

Background

The DRD2 Dopamine Receptor is involved in the neuromodulation of appetitive behaviors. DRD2 may be linked to alcoholism and other substance-use disorders. Mutations in DRD2 in mice lead to the suppression of reward behavior with morphine and to the reduction of spontaneous movements, a phenotype resembling Parkinson's disease. Three alternatively spliced isoforms have been identified. DRD2 has been reported to be expressed in various regions of the brain, as well as in aorta, artery, eye, and spinal cord. ESTs have been isolated from normal pituitary and in brain, colon, lung, pancreas, and skeletal muscle cancer libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Dopamine D2R/DRD2 Antibody (NB600-1261)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC/IF.


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ICC/IF
(1)
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Bioinformatics

Gene Symbol DRD2
Entrez
Uniprot