DNMT3A Antibody (64B1446) 0.1 mg

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Western Blot: DNMT3A Antibody (64B1446) [NB120-13888] - NTERA-2 cells were treated with Zebularine as indicated for 24 hours. Cell lysates were prepared and separated on a 7.5% gel by SDS-PAGE. Protein was transferred to PVDF membrane and blocked in 5% non-fat milk. The membrane was probed with 2 ug/ml anti-Dnmt3a in 1% milk, and detected with an anti-mouse HRP secondary antibody using chemiluminescence. Note the decrease in Dnmt3a expression upon treatment with 500 uM Zebularine (arrowhead). Additional bands at 90 and 75 kDa can also be detected with this antibody and may represent alternative splice variants.  Tubulin is shown as a loading control
Immunocytochemistry/Immunofluorescence: DNMT3A Antibody (64B1446) [NB120-13888] - Ntera2 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-DNMT3A (68B1446) [NB120-13888] at a 1:200 dilution overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:500 dilution. Actin was detected with Phalloidin 568 (Red) at a 1:200 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.
Immunohistochemistry-Paraffin: DNMT3A Antibody (64B1446) [NB120-13888] - IHC-P detection of DNMT3A on human hepatocellular carcinoma tissue section (NBP2-30221) using 1:100 dilution of DNMT3A antibody (clone 64B1446). The antibody generated a specific cytoplasmic staining in all the cancer cells while some of the cells depicted nuclear staining also.
Flow Cytometry: Dnmt3a Antibody (64B1446) [NB120-13888] - Intracellular flow cytometric staining of 1 x 10^6 CHO (A) and HEK-293 (B) cells using Dnmt3a antibody (dark blue). Isotype control shown in orange. An antibody concentration of 1 ug/1x10^6 cells was used.
Western Blot: Dnmt3a Antibody (64B1446) [NB120-13888] - Analysis of (A) Dnmt3a transfected 293 cell lysate and (B) untransfected 293 cell lysate using Dnmt3a antibody at 1 ug/ml.
Immunocytochemistry/Immunofluorescence: Dnmt3a Antibody (64B1446) [NB120-13888] - Expression of Dnmt3a in the nuclei of post-mitotic neurons in the olfactory epithelium (OE). DNMT3a (red) is co-expressed with neuron-specific tubulin (green) throughout the development of the olfactory epithelium. (Data courtsey of A. Jane Roskams, University of British Columbia).
Immunohistochemistry-Paraffin: Dnmt3a Antibody (64B1446) [NB120-13888] - Formalin-fixed, paraffin-embedded human liver stained with Dnmt3a antibody at 5 ug/ml.    Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.
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Ordering Information: NB120-13888

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  • Also Known As
    Imgenex: IMG-268A
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DNMT3A Antibody (64B1446) Summary

Species Human, Mouse
Tested Applications WB, ChIP, Flow, ICC/IF, IHC-P, IHC-WhMt
Protein G purified
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DNMT3A Antibody (64B1446) Details

IgG1 Kappa
This DNMT3A antibody was raised against bacteria expressed recombinant mouse Dnmt3a. The epitope was found to lie near the C-terminus (a.a. 705-908), see Chen et (2002) for details.

Species Reactivity

Publications Read Publications using NB120-13888 in the following species:


  • Western Blot 2 ug/ml
  • Chromatin Immunoprecipitation
  • Flow Cytometry 1 ug per million cells
  • Immunocytochemistry/Immunofluorescence 1:50-1:100
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Immunohistochemistry Whole-Mount
Application Notes
Western Blot: Detects a band of approximately 120 kDa (predicted molecular weight: 102 kDa). Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min. Use in chromatin immunoprecipitation reported in scientific literature (PMID 24623306). Use in Immunohistochemistry whole mount reported in scientific literature (PMID 26507142).
Positive Controls
Other Available
Alexa Fluor (R) 405 Labeled NB120-13888AF405
Alexa Fluor (R) 488 Labeled NB120-13888AF488
Alexa Fluor (R) 647 Labeled NB120-13888AF647
Alexa Fluor (R) 700 Labeled NB120-13888AF700
Allophycocyanin Labeled NB120-13888APC
DyLight 350 Labeled NB120-13888UV
DyLight 405 Labeled NB120-13888V
DyLight 405LS Labeled NB120-13888V3
DyLight 488 Labeled NB120-13888G
DyLight 550 Labeled NB120-13888R
DyLight 650 Labeled NB120-13888C
DyLight 680 Labeled NB120-13888FR
DyLight 755 Labeled NB120-13888IR
HRP Labeled NB120-13888H
PE Labeled NB120-13888PE
PerCP Labeled NB120-13888PCP
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NB120-13888 in the following applications:

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DNMT3A Antibody (NB120-13888) has been mentioned in at least 76 publications.
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Unit Size
0.1 mg
1.0 mg/ml
0.05% Sodium Azide
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.


Gene Symbol DNMT3A

Alternate Names for DNMT3A Antibody (64B1446)

  • anti-64B1446 clone
  • DNA (cytosine-5-)-methyltransferase 3 alpha
  • DNA (cytosine-5)-methyltransferase 3A
  • DNA cytosine methyltransferase 3A2
  • DNA methyltransferase HsaIIIA
  • DNA MTase HsaIIIA
  • Dnmt3a
  • DNMT3A2
  • EC
  • M.HsaIIIA
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Related Products by Gene


Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of Dnmt3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.
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Publications for DNMT3A Antibody (NB120-13888) (76)

Read what people are writing who have used DNMT3A Antibody (NB120-13888).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 7 applications: WB, ChIP, ICC/IF, IHC, IHC-Fr, IHC-P, IHC-WhMt.

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Fan H, Liu D, Qiu X et al. A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma. BMC Med. 2010 Feb 3 [PMID: 20128888]
Chen T, Ueda Y, Xie S, Li E. A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. J Biol Chem. 2002 Oct 11 [PMID: 12138111]
Park IY, Sohn BH, Yu E et al. Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein. Gastroenterology. 2007 Apr [PMID: 17408664] (WB)

(Chang liver and Hep G2 cell lines): 1. IMG-261(DNMT1): WB, Figs. 1A, 4A,B. 2. IMG-268A (DNMT3A): WB, ChIP, Figs. 1B, 2B, 4A,B.
Shen Y, Chow J, Wang Z, Fan G. Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells. Hum Mol Genet. 2006 Sep 1 [PMID: 16870691] (ICC/IF) ICC/IF
Zimmermann N, Zschocke J, Perisic T et al. Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels. Biochem J. 2012 Nov 15 [PMID: 22880885]
Stadtfeld M, Apostolou E, Ferrari F et al. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet. 2012 Mar 4 [PMID: 22387999]
Yan Q, Cho E, Lockett S, Muegge K. Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin. Mol Cell Biol. 2003 Dec [PMID: 14612388]
Wu Y, Alvarez M, Slamon DJ et al. Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. BMC Cancer. 2010 Feb 4 [PMID: 20132554]
Stempak JM, Sohn KJ, Chiang EP et al. Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model. Carcinogenesis. 2005 May [PMID: 15695236]
Lucifero D, La Salle S, Bourc'his D et al. Coordinate regulation of DNA methyltransferase expression during oogenesis. BMC Dev Biol. 2007 Apr 19 [PMID: 17445268] (WB, Mouse)

Products cited for WB (growing mouse oocytes and type B spermatogonia): 1. DNMT3a (IMG-268A), Fig 5a, b (middle panel). The antibody detected both the DNMT3a (908 aa) and DNMT3a2 (689 aa) isoforms. 2. DNMT3b (IMG-184A), Fig 5c (top panel). The antibody de
WB Mouse
Pawlak M, Jaenisch R. De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state. Genes Dev. 2011 May 15 [PMID: 21576263]
Oka M, Meacham AM, Hamazaki T et al. De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine. Oncogene. 2005 Apr 28 [PMID: 15735669]
Park IY, Sohn BH, Choo JH et al. Deregulation of DNA methyltransferases and loss of parental methylation at the insulin-like growth factor II (Igf2)/H19 loci in p53 knockout mice prior to tumor development. J Cell Biochem. 2005 Feb 15 [PMID: 15543560]
Iwatani M, Ikegami K, Kremenska Y et al. Dimethyl sulfoxide has an impact on epigenetic profile in mouse embryoid body. Stem Cells. 2006 Nov [PMID: 16840553]
Nasonkin IO, Lazo K, Hambright D et al. Distinct nuclear localization patterns of DNA methyltransferases in developing and mature mammalian retina. J Comp Neurol. 2011 Jul 1 [PMID: 21452232]
Kashiwagi K, Nimura K, Ura K, Kaneda Y. DNA methyltransferase 3b preferentially associates with condensed chromatin. Nucleic Acids Res. 2011 Feb [PMID: 20923784]
Kadriu B, Guidotti A, Chen Y, Grayson DR. DNA methyltransferases1 (DNMT1) and 3a (DNMT3a) colocalize with GAD67-positive neurons in the GAD67-GFP mouse brain. J Comp Neurol. 2012 Jun 15 [PMID: 22134929] (WB, IHC-Fr, Mouse)

Antibodies cited: 1. DNMT1 (IMG-261A): WB (mouse brain cortical extracts), Table 1; IHC (frozen) (mouse brain), Figs 5, 6, 8B, 8C. 2. DNMT3A (IMG-268A): WB (mouse brain cortical extracts), Table 1; IHC (frozen) (mouse brain), Fig 7. Note: The specificitie
IHC-Fr, WB Mouse
Nimura K, Ishida C, Koriyama H et al. Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation. Genes Cells. 2006 Oct [PMID: 16999741]
Linhart HG, Lin H, Yamada Y et al. Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev. 2007 Dec 1 [PMID: 18056424] (WB, Mouse)

Products cited (mouse tumor cells): 1. IMG-184A (Dnmt3b): IHC (paraffin); Figs. 1C, 2A. Dnmt3b transgene validated in mice in Figs. 1C, 2A. 2. IMG-268A (Dnmt3a): IHC (paraffin), Wb; Figs. 1C, 2A,B. Dnmt3a transgene validated in mice in Figs. 1C, 2A,B.
WB Mouse
Feng J, Chang H, Li E, Fan G. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res. 2005 Mar 15 [PMID: 15672446]
La Salle S, Trasler JM. Dynamic expression of DNMT3a and DNMT3b isoforms during male germ cell development in the mouse. Dev Biol. 2006 Aug 1 [PMID: 16725135] (WB, Mouse)

Products cited for WB (primary male mouse germ cells and testes): 1. DNMT3a (IMG-268A), Fig 5B (middle panel). The antibody detected both the DNMT3a (908 aa) and DNMT3a2 (689 aa) isoforms. 2. DNMT3b (IMG-184A), Fig 5C (top panel). The antibody detected mu
WB Mouse
Sheikh MA, Malik YS, Yu H et al. Epigenetic regulation of Dpp6 expression by Dnmt3b and its novel role in the inhibition of RA induced neuronal differentiation of P19 cells. PLoS One. 2013 [PMID: 23409053]
Ko CY, Hsu HC, Shen MR et al. Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex. J Biol Chem. 2008 Nov 7 [PMID: 18753137] (WB)

HeLa cells in Fig. 7A (IF), 7B (WB following a DNA Affinity Precipitation Assay of nuclear extracts), 7C and D (ChIP): 1. IMG-261A (Dnmt1) 2. IMG-268A (Dnmt3a) 3. IMG-184A (Dnmt3b).
Chen T, Ueda Y, Dodge JE et al. Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol Cell Biol. 2003 Aug [PMID: 12897133] (WB, Mouse)

WB [mouse embryonic stem (ES) cell lines and ES cells expressing various Dnmt1, 3a and 3b isoforms], Figs 1B and 7A.
WB Mouse
Choi MS, Shim YH, Hwa JY et al. Expression of DNA methyltransferases in multistep hepatocarcinogenesis. Hum Pathol. 2003 Jan [PMID: 12605361]
Galetzka D, Tralau T, Stein R, Haaf T. Expression of DNMT3A transcripts and nucleolar localization of DNMT3A protein in human testicular and fibroblast cells suggest a role for de novo DNA methylation in nucleolar inactivation. J Cell Biochem. 2006 Jul 1 [PMID: 16453278]
Xia G, Schneider-Stock R, Diestel A et al. Helicobacter pylori regulates p21(WAF1) by histone H4 acetylation. Biochem Biophys Res Commun. 2008 May 2 [PMID: 18302936] (WB, Human)

(human NCI N87 gastric carcinoma cells): WB (Fig 1) 1. Dnmt1 (IMG-261). 2. Dnmt3a (IMG-268) 3. Dnmt3b (IMG-184).
WB Human
Park ES, Park YK, Shin CY et al. Hepatitis B virus inhibits liver regeneration via epigenetic regulation of urokinase-type plasminogen activator. Hepatology. 2013 Aug [PMID: 23483589]
Qiu YY, Mirkin BL, Dwivedi RS. Inhibition of DNA methyltransferase reverses cisplatin induced drug resistance in murine neuroblastoma cells. Cancer Detect Prev. 2005 [PMID: 16185816]
Jones B, Chen J. Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development. EMBO J. 2006 Jun 7 [PMID: 16724115] (ChIP) ChIP
Dennis K, Fan T, Geiman T et al. Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev. 2001 Nov 15 [PMID: 11711429]
Tsumura A, Hayakawa T, Kumaki Y et al. Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells. 2006 Jul [PMID: 16824199]
Hirasawa R, Chiba H, Kaneda M et al. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev. 2008 Jun 15 [PMID: 18559477] (IF/ICC, Mouse)

Antibodies cited: 1. Dnmt3a (IMG-268a): IF/ICC (mouse oocytes and embryos), Fig. 1a. 2. Dnmt3b (IMG-184): IF/ICC (mouse occytes and embryos), Fig. 1c.
May A, Kirchner R, Muller H et al. Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres. Biol Reprod. 2009 Jan [PMID: 18784354] (IF/ICC, Mouse)

IF/ICC (mouse blastomeres), Fig. 5A.
Leitch HG, McEwen KR, Turp A et al. Naive pluripotency is associated with global DNA hypomethylation. Nat Struct Mol Biol. 2013 Mar [PMID: 23416945]
Meilinger D, Fellinger K, Bultmann S et al. Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO Rep. 2009 Nov [PMID: 19798101]
Selvakumar T, Gjidoda A, Hovde SL, Henry RW. Regulation of human RNA polymerase III transcription by DNMT1 and DNMT3a DNA methyltransferases. J Biol Chem. 2012 Mar 2 [PMID: 22219193]
Weisenberger DJ, Velicescu M, Cheng JC et al. Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation. Mol Cancer Res. 2004 Jan [PMID: 14757847] (WB)

Products cited for WB [wild-type mouse embryonic stem (ES) cells and ES knockouts of Dnmt3a, Dnmt3b, and 3a/b]: 1. DNMT3a (IMG-268A), Fig 2A, B. The specificity of the antibody is knockout mouse validated as it did not detect Dnmt3a in either the 3a-/- (M
Ueda Y, Okano M, Williams C et al. Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development. 2006 Mar [PMID: 16501171]
Hong GM, Bain LJ. Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1. Toxicol Appl Pharmacol. 2012 May 1 [PMID: 22426358]
MacDonald JL, Gin CS, Roskams AJ. Stage-specific induction of DNA methyltransferases in olfactory receptor neuron development. Dev Biol. 2005 Dec 15 [PMID: 16288735] (IHC-P) IHC-P
Hara ES1, Ono M1, Eguchi T2 et al. miRNA-720 Controls Stem Cell Phenotype, Proliferation and Differentiation of Human Dental Pulp Cells. PLoS One 2013 Dec 30 [PMID: 24386225] (ICC/IF, Human) ICC/IF Human
Wongtrakoongate P, Li J, Andrews PW. DNMT3B inhibits the re-expression of genes associated with induced pluripotency. Exp Cell Res 2013 Dec 10 [PMID: 24333507] (WB, Human) WB Human
Zhou JX, Dhawan S, Fu H et al. Combined modulation of polycomb and trithorax genes rejuvenates beta cell replication. J Clin Invest 2013 Oct 8 [PMID: 24216481] (WB, Mouse) WB Mouse
Hara S, Takano T, Fujikawa T et al. Forced expression of DNA methyltransferases during oocyte growth accelerates the establishment of methylation imprints but not functional genomic imprinting. Hum. Mol. Genet. 2014 Mar 18 [PMID: 24599402] (WB, Mouse)

Mouse WT oocytes and oocytes DNMT3A2 transgenic mice, Figs 1, 2D-E, 4A. The mAb detected both 3A (130 kDa) and the smaller 3A2 (85 kDa) isoforms. DNMT3A2 is a short DNMT3A isoform produced from an alternative promoter. Note: The specificity of the antibod
WB Mouse
Hara S, Takano T, Ogata M et al. Establishment of a Conditional Transgenic System Using the 2A Peptide in the Female Mouse Germline. J. Reprod. Dev. 2014 Mar 15 [PMID: 24632680] (WB, Mouse)

DNMT3A2-transgenic mouse models amd DNMT3A2-transfected cells (Figs 1C, 2E, F). DNMT3A2 was detected at approx. 85 kDa (Fig 1C), DNMT3A1 was detected at approx. 135kDa (Fig 2E). The specificity of the DNMT3A mAb was validated in DNMT3A2 transgenic mouse m
WB Mouse
Obata Y, Wakai T, Hara S, Kono T et al. Long exposure to mature ooplasm can alter DNA methylation at imprinted loci in non-growing oocytes but not in prospermatogonia. Reproduction. 2014 Jan 1 [PMID: 24123131] (ICC/IF, Mouse)

Oocyte/prospermatogonium fusions, Fig 3.
ICC/IF Mouse
Serra FW, Fang M, Park SM et al. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 2014 [PMID: 24623306] (ChIP, Human) ChIP Human
Paredes-Gonzalez X, Fuentes F, Su ZY, Kong AN. Apigenin Reactivates Nrf2 Anti-oxidative Stress Signaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications. AAPS J. 2014 May 16 [PMID: 24830944] (WB, Mouse)

JB6 P+ mouse skin epidermal cells, Fig 6a.
WB Mouse
Leu YW, Yan PS, Fan M et al. Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer. Cancer Res. 2004 Nov 15 [PMID: 15548683] (ChIP) ChIP
Guimaraes DM, Antunes DM, Duarte CM et al. DNA methyltransferase immunohistochemical expression in odontogenic tumours J. Oral Pathol. Med. 2014 Jul 24 [PMID: 25060239] (IHC-P, Human)

Dnmt3a antibody used for IHC-P at 1:200 dilution on formalin-fixed and paraffin-embedded tissue sections of human ameloblastomas, calcifying cystic odontogenic tumours, calcifying epithelial tumours, adenomatoid odontogenic tumours, keratocystic odontogenic tumours, ameloblastic fibromas, ameloblastic fibro-odontomas, central odontogenic fibromas, peripheral odontogenic fibromas and odontogenic myxomas.
IHC-P Human
Emperle M, Rajavelu A, Reinhardt R et al. Cooperative DNA binding and protein/DNA fiber formation increases the activity of the Dnmt3a DNA methyltransferase J. Biol. Chem. 2014 Aug 21 [PMID: 25147181] (WB) WB
Wang L, Zhang C, Guo Y et al. Blocking of JB6 Cell Transformation by Tanshinone IIA: Epigenetic Reactivation of Nrf2 Antioxidative Stress Pathway. AAPS J. 2014 Nov 01 [PMID: 25274607] (WB, Mouse)

DNMT3a antibody used for WB on lysates of JB6 P+ cells (a mouse keratinocyte cell line) treated or not with Tanshinone IIA (TIIA), an active component in Salvia miltiorrhiza that has been reported to activate Nrf2 pathway.
WB Mouse
Huichalaf C, Micheloni S, Ferri G et al. DNA Methylation Analysis of the Macrosatellite Repeat Associated with FSHD Muscular Dystrophy at Single Nucleotide Level. PLoS ONE. 2014 Dec 30 [PMID: 25545674] (ChIP, Human)

DNMT3A antibody used for ChIP in experiments involving human chromosome 4/CHO (Chr4/CHO) hybrid cells (a human-hamster hybrid cell line).
ChIP Human
Guo Y, Shu L, Zhang C et al. Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1 Biochem. Pharmacol. 2015 Jan 29 [PMID: 25640947] (WB, Human)

DNMT3A antibody used for WB on lysates of HT29 human colon cancer cells treated or not with 2.5uM or 5uM Curcumin, and 2.5uM azadeoxycytidine/5AZA + 100uM trichostatin A/TSA. Curcumin was found to downregualte the expression levels of DNMT3A protein in a concentration-dependent manner (Fig 5).
WB Human
Neri F, Incarnato D, Krepelova A et al. Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics Cell Rep. 2015 Feb 04 [PMID: 25660018] (WB, Mouse)

DNMT3A antibody (clone 64B1446) used for WB analysis of lysates from mouse embryonic stem cell / mESCs which were transfected with either control shRNA (shCtr) or shRNAs targeting Dnmts namely Sh-Dnmt1, Sh-Dnmt3a, Sh-Dnmt3b and Sh-Dnmt3a/b (Figure 4E).
WB Mouse
Robaina MC, Mazzoccoli L, Arruda VO et al. Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis Exp. Mol. Pathol. 2015 Mar 04 [PMID: 25746661] (IHC-P, Human)

DNMT3A antibody (clone 64B1446) was used at 1:100 dilution for IHC-P application on tissue microarray /TMA slides of Burkitt lymphoma tissues with placental tissue included as positive control (Fig. 1).
IHC-P Human
Yang Jian, Wei Xiaowei, Wu Qingxiang et al. Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer. Mol Med Rep. 2011 Nov-Dec [PMID: 21887466] (IHC, Human) IHC Human
Lambrot R, Kimmins S. Histone methylation is a critical regulator of the abnormal expression of POU5F1 and RASSF1A in testis cancer cell lines. Int J Androl. 2011 Apr [PMID: 20497257] (WB, Human) WB Human
Park Hye-Jung, Yu Eunsil, Shim Yhong-Hee. DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. Cancer Lett. 2006 Feb 28 [PMID: 15885882] (Human) Human
Oh Bong-Kyeong, Kim Haeryoung, Park Hye-Jung et al. DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation. Int J Mol Med. 2007 Jul [PMID: 17549390] (Human) Human
Daniel Filipe Ivan, Rivero Elena Riet Correa, Modolo Filipe et al. Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas. Arch Oral Biol. 2010 Dec [PMID: 20951977] (Human) Human
Lahousse S A, Hoenerhoff M, Collins J et al. Gene expression and mutation assessment provide clues of genetic and epigenetic mechanisms in liver tumors of oxazepam-exposed mice. Vet Pathol. 2011 Jul [PMID: 21147764] (IHC, Mouse) IHC Mouse
Molognoni Fernanda, Cruz Adriana T, Meliso Fabiana M et al. Epigenetic reprogramming as a key contributor to melanocyte malignant transformation. Epigenetics. 2011 Apr [PMID: 21343701] (WB, Mouse) WB Mouse
Takahashi Mayumi, Kamei Yasutomi, Ehara Tatsuya et al. Analysis of DNA methylation change induced by Dnmt3b in mouse hepatocytes. Biochem Biophys Res Commun. 2013 May 17 [PMID: 23611774] (Mouse) Mouse
Zhu Feng, Xia Xiaojun, Liu Bigang et al. IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing. Mol Cell. 2007 Jul 20 [PMID: 17643371] (ChIP) ChIP
Kurdikova Vendula, Smolinsky Radovan, Gvozdik Lumir. Mothers matter too: benefits of temperature oviposition preferences in newts. PLoS One. 2011 [PMID: 21887330] (WB) WB
Chuang C-H, Wang W-J, Li C-F et al. The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer. Cell Death Dis. 2014 [PMID: 24810056] (WB) WB
Pierard Valerie, Guiguen Allan, Colin Laurence et al. DNA cytosine methylation in the bovine leukemia virus promoter is associated with latency in a lymphoma-derived B-cell line: potential involvement of direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator/activation transcription factor binding. J Biol Chem. 2010 Jun 18 [PMID: 20413592] (WB) WB
Dhawan S, Tschen SI, Zeng C et al. DNA methylation directs functional maturation of pancreatic B cells J. Clin. Invest. 2015 Jul 01 [PMID: 26098213] (IHC-P, Mouse) IHC-P Mouse
Tsukada Y, Akiyama T, Nakayama KI. Maternal TET3 is dispensable for embryonic development but is required for neonatal growth. Sci Rep. 2015 Oct 28 [PMID: 26507142] (IHC-WhMt, ICC/IF, Mouse)

DNMT3a antibody was used for ICC/IF and IHC-whole mount staining of fully grown oocytes at the germinal vesicle stage and zygotes produced by in vitro fertilization in experiments involving Tet3 conditional knockout mice. The IHC protocol involved 20?minutes of fixation at RT in 4% PFA-PBS with 0.2% Triton X-100, 1 hour blocking with 1% BSA -0.05% Tween 20, ON incubation with DNMT3a antibody at 1:1000 dilution, detection using AF568-conjugated secondary (see full text for detailed protocol).
ICC/IF, IHC-WhMt Mouse
Li Y, Seah MK, O'Neill C. Mapping global changes in nuclear cytosine base modifications in the early mouse embryo. Reproduction. 2016 Feb 01 [PMID: 26660107] (IHC-WhMt, Mouse)

DNMT3A Antibody (clone 64B1446; Imgenex IMG-268A) was used for immunofluorescence staining of the murine whole embryos which were fixed at in 4% formaldehyde for 30?minutes at room temperature and permeabilized in 0.5% Tween20 & Triton X100. The primary antibody was used at 1:1000 dilution (see full text for detailed protocol).
IHC-WhMt Mouse
Amouroux R, Nashun B, Shirane K et al. De novo DNA methylation drives 5hmC accumulation in mouse zygotes. Nat. Cell Biol. 2016 Feb 01 [PMID: 26751286] (ICC/IF, Mouse) ICC/IF Mouse
Hong B, Su Z, Zhang C et al. Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway. AAPS J. 2016 Mar 17 [PMID: 26988984] (WB, Mouse) WB Mouse
Dhawan S, Dirice E, Kulkarni RN, Bhushan A. Inhibition of TGF-beta signaling promotes human pancreatic beta cell replication. Diabetes. 2016 Mar 02 [PMID: 26936960] (WB, Human) WB Human
Xu X, Tan X, Hulshoff MS et al. Hypoxia-induced endothelial-mesenchymal transition is associated with RASAL1 promoter hypermethylation in human coronary endothelial cells. FEBS Lett. 2016 Apr 01 [PMID: 27012941] (WB, Human) WB Human

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FAQs for DNMT3A (1)

  1. Do you have any information about the epitope of your antibody, so I could check the chances for the antibody working in the honey bee?
    • This antibody was raised against bacteria expressed recombinant mouse Dnmt3a. The epitope was found to lie near the C-terminus (a.a. 705-908), see Chen et (2002) for details. We haven't mapped the binding binding epitope although Chen et (2002) mapped it to a range between 705-908 amino acids: I am not sure what technique you are planning with the antibody, but if you are doing a western blot, we do have a western blot postive control ready to use lysate NBP2-25063 and I would l highly suggest using that.

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Mouse Monoclonal
Species Human, Mouse, Rat...MORE
Applications WB, Simple Western, ChIP...MORE

     2 Reviews

95 Publications
Western Blot: DNMT3B Antibody (52A1018) [NB100-56514] - Dnmt3b Antibody (52A1018) [NB100-56514] - Analysis of lysates from 293 cells transfected with mouse Dnmt3a (Lanes 1) and Dnmt3b (Lanes 2). Immunocytochemistry/Immunofluorescence: DNMT3B Antibody (52A1018) [NB100-56514] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100.  The cells were incubated with primary antibody at a 1:200 dilution overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:500 dilution.  Actin was detected with Phalloidin 568 (Red) at a 1:200 dilution.  Nuclei were counterstained with DAPI (Blue).  Cells were imaged using a 40X objective.Flow Cytometry: Dnmt3b Antibody (52A1018) [NB100-56514] - Intracellular flow cytometric staining of 1 x 10^6 CHO (A) and HEK-293 (B) cells using Dnmt3b antibody (dark blue). Isotype control shown in orange. An antibody concentration of 1 ug/1x10^6 cells was used.

Mouse Monoclonal
Species Human, Mouse
Applications WB, Simple Western, ChIP...MORE

     2 Reviews

89 Publications
Western Blot: Dnmt3L Antibody [NBP2-27098] - Analysis of Dnmt3L using Dnmt3L antibody. GST tagged full length recombinant human Dnmt3L probed with 1) prebleed and 2) Dnmt3L antibody at 2 ug/ml.  Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.Immunohistochemistry-Paraffin: Dnmt3L Antibody [NBP2-27098] - Analysis of Dnmt3L in human kidney using Dnmt3L antibody at 5 ug/ml.

Rabbit Polyclonal
Species Human, Primate
Applications WB, IHC-P

1 Publication
Western Blot: p19ARF Antibody [NB200-106] - WB analysis of p19ARF in 1. NIH/3T3 and B. MEF cell lysate.Immunocytochemistry/Immunofluorescence: p19ARF Antibody [NB200-106] - p19ARF antibody was tested in MEF cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

Rabbit Polyclonal
Species Mouse
Applications WB, ELISA, ICC/IF...MORE

39 Publications
Western Blot: MeCP2 Antibody [NB100-56326] - analysis of MeCP2 in HeLa cell lysate using this antibody.Immunocytochemistry/Immunofluorescence: MeCP2 Antibody [NB100-56326] - MeCP2 antibody was tested in A431 cells at a 1:200 dilution against Dylight 488 (Green). Alpha tubulin and nuclei were counterstained against Dylight 568 (Red) and DAPI (Blue), respectively.Immunohistochemistry-Paraffin: MeCP2 Antibody [NB100-56326] - IHC analysis of a formalin fixed paraffin embedded section of mouse liver tissue using MeCP2 antibody at 1:500 dilution. The antibody generated a very strong/specific nuclear staining with weak to negligible cytoplasmic signal in the hepatocytes, kupffer cells, and in the endothelial cells of blood vessels.

Rabbit Polyclonal
Species Human, Mouse
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1 Publication
Western Blot: MBD2 Antibody [NB100-81656] - Detection of Human MBD2 by Western Blot of  Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP,  20% of IP loaded) from HeLa cells. Antibodies: Affinity purified  rabbit anti-MBD2 antibody NB100-81656 used for IP at 3 mcg/mg  lysate. MBD2 was also immunoprecipitated by rabbit anti-  MBD2 antibody NB100-81657, which recognizes a downstream  epitope. Detection:  Chemiluminescence with an exposure time of 3 secondsImmunocytochemistry/Immunofluorescence: MBD2 Antibody [NB100-81656] - Human breast carcinoma Affinity purified rabbit anti-MBD2 used at a dilution of 1:100.  Detection: Red-fluorescent goat anti-rabbit IgG highly crossadsorbed Antibody used at a dilution of 1:100.Immunohistochemistry-Paraffin: MBD2 Antibody [NB100-81656] - Human breast carcinoma  Affinity purified rabbit anti-MBD2 used at a dilution of 1:100. Detection: Red-fluorescent goat anti-rabbit IgG highly crossadsorbed Antibody used at a dilution of 1:100.

Rabbit Polyclonal
Species Human, Mouse
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Western Blot: HDAC1 Antibody [NB100-56340] - analysis of HDAC1 in 293 cell lysate with this antibody.Simple Western: HDAC1 Antibody [NB100-56340] - Simple Western lane view shows a specific band for HDAC1 in 0.5 mg/ml of Hek293 lysate.  This experiment was performed under reducing conditions using the 12-230 kDa separation system.

Rabbit Polyclonal
Species Human, Mouse, Rat
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     1 Review

9 Publications
Western Blot: Histone H3 Antibody [NB500-171] - Total histone H3 levels in MCF-7 and HCT-116 cells. Image from verified customer review.Immunohistochemistry: Histone H3 Antibody [NB500-171] - Analysis of Histone H3 in human breast cancer using DAB with hematoxylin counterstain.Chromatin Immunoprecipitation: Histone H3 Antibody [NB500-171] - Chromatin from one million formaldehyde cross-linked HeLa cells was precipitated using 2 ug of NB500-171 and 25 ul of magnetic IgG beads, using standard ChIP methods. A similar sample containing no antibody (No Ab) was included as a negative control. Immunoprecipitated DNA was quantified using quantitative real-time PCR and SYBR green dye, then normalized to the non-precipitated input chromatin. Representative target genes from active, inactive and heterochromatic regions of the genome show amplification, indicative of the presence of Histone H3.

Rabbit Polyclonal
Species Human, Mouse, Rat...MORE
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     2 Reviews

5 Publications
Immunohistochemistry-Paraffin: p21/CIP1/CDKN1A Antibody (WA-1 (HJ21)) [NBP2-29463] - Formalin-fixed, paraffin-embedded human bladder carcinoma stained with p21 Monoclonal Antibody (WA-1).

Mouse Monoclonal
Species Human, Mouse, Rat...MORE
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9 Publications
Western Blot: Isocitrate Dehydrogenase 1/IDH1 Antibody (2H9) [NBP1-47804] - Analysis of extracts (35ug) from 9 different cell lines by using anti-Isocitrate dehydrogenasemonoclonal antibody.Immunocytochemistry/Immunofluorescence: Isocitrate Dehydrogenase 1/IDH1 Antibody (2H9) [NBP1-47804] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY Isocitrate dehydrogenase.Immunohistochemistry-Paraffin: Isocitrate Dehydrogenase 1/IDH1 Antibody (2H9) [NBP1-47804] - Endometrium tissue.

Mouse Monoclonal
Species Human, Monkey
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     1 Review

Western Blot: ASXL1 Antibody (6E2) [H00171023-M05] - Analysis of ASXL1 expression in MCF-7 (Cat # L046V1).Sandwich ELISA: ASXL1 Antibody (6E2) [H00171023-M05] - Detection limit for recombinant GST tagged ASXL1 is 0.3 ng/ml as a capture antibody.

Mouse Monoclonal
Species Human
Applications WB, ELISA, S-ELISA

2 Publications
Western Blot: OCT4 Antibody [NB100-2379] - Detection of OCT4 in mouse brain lysate.Immunocytochemistry/Immunofluorescence: OCT4 Antibody [NB100-2379] - OCT4 staining in NTERA-2 cells detected with a Dylight 488 labeled secondary antibody.Flow Cytometry: OCT4 Antibody [NB100-2379] - Staining of NTERA-2  cells using NB100-2379 at a 1:50 dilution detected using Dylight-488 conjugated goat anti-rabbit secondary antibody.

Rabbit Polyclonal
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Applications WB, Flow, ICC/IF

8 Publications
Western Blot: TET2 Antibody [NBP2-32104] - Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells.  Antibodies:  Affinity purified rabbit anti-TET2 antibody NBP2-32104  used for IP at 6 ug/mg lysate.  TET2 was also immunoprecipitated by rabbit anti-TET2 antibody BL16766.  For blotting immunoprecipitated TET2, NBP2-32104 was used at 1 ug/ml.  Detection: Chemiluminescence with an exposure time of 3 minutes.Immunohistochemistry: TET2 Antibody [NBP2-32104] - Section of human ovarian carcinoma.  Western Blot: TET2 Antibody [NBP2-32104] - Whole cell lysate from HeLa, 293T, and Jurkat cells.  Antibodies:

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC-P...MORE

     1 Review

Western Blot: Flt-3/Flk-2/CD135 Antibody (7E8.2C8) [NBP2-42210] - WB analysis of lysates from (A) Human Embryonic Kidney 293 / HEK293 and (B) Human Embryonic carcinoma NCCIT cell lines using Flt-3/Flk-2/CD135 antibody (clone 7E8.2C8) at 2ug/ml concentration. The antibody detected single specific bands in both samples at the expected molecular weight position. Immunohistochemistry-Paraffin: Flt-3/Flk-2/CD135 Antibody (7E8.2C8) [NBP2-42210] - IHC analysis of a formalin fixed paraffin embedded tissue section of human liver cancer using Flt-3/Flk-2/CD135 antibody (clone 7E2.2C8) at 15 ug/ml concentration. The antibody generated specific cytoplasmic immunostaining of FLT3 in the cancerous cells while the tumor stroma was largely negative for the staining. Flow Cytometry: Flt-3/Flk-2/CD135 Antibody (7E8.2C8) [NBP2-42210] - HEK293 cells were stained (surface) with Flt-3/Flk-2/CD135 antibody (clone: 7E8.2C8; red) or isotype control (mouse IgG2 lambda; blue) and positive staining observed using PE conjugated mouse anti-IgG(H+L) secondary antibody. Live cells (PPI negative) were gated for analysis

Mouse Monoclonal
Species Human
Applications WB, Flow, IHC...MORE

Western blot shows lysates of MCF‑7 human breast cancer cell line untreated (-) or treated (+) with 1 µM Camptothecin (CPT) for 5 hours. PVDF membrane was probed with 1:1000 dilution of Rabbit Anti-Human Phospho-p53 (S46) Monoclonal Antibody (Catalog # MAB1489) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band was detected for phospho-p53 (S46) at approximately 53 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Rabbit Monoclonal
Species Human
Applications WB

Immunohistochemistry: DPEP2 Antibody [NBP1-86304] - Staining of human kidney shows strong cytoplasmic positivity in tubular and glomerular cells.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

Western Blot: Dnmt2 Antibody [NB200-616] - Homogenized mouse brain cells. Image from verified customer review.Western Blot: Dnmt2 Antibody [NB200-616] - analysis of Dnmt2 in mouse ES cell lysate using Dnmt2 antibodyat 2 ug/ml.Western Blot: Dnmt2 Antibody [NB200-616] - Western blot analysis for Dnmt2a using NB200-616 at 2 ug/ml dilution against 10 ug of mouse testis lysates. A protein band of approximate mol. wt. of 42 kDa is detected.

Rabbit Polyclonal
Species Human, Mouse
Applications WB

     1 Review

2 Publications
Western Blot: Nucleophosmin Antibody [NB110-61646] - Detection of mutant Nucleophosmin in OCI-AML3 lysates.Immunocytochemistry/Immunofluorescence: Nucleophosmin Antibody [NB110-61646] - Nucleophosmin localization by immunofluorescence in HL-60 cells (negative control).Immunocytochemistry/Immunofluorescence: Nucleophosmin Antibody [NB110-61646] - Nucleophosmin antibody was tested in HeLa cells with FITC (green). Nuclei and alpha-tubulin were counterstained with Dapi (blue) and Dylight 550 (red).

Rabbit Polyclonal
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Bioinformatics Tool for DNMT3A

Discover related pathways, diseases and genes to DNMT3A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Bioinformatics Tool
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Blogs on DNMT3A

Check out the latest blog posts on DNMT3A.
Go Ahead! Make My DNA
DNA methylation plays a critical role the long-term silencing of transcription and is essential for processes such as embryonic development, germline differentiation, and tissue maturation. Dnmt3a is a member of the C5-methyltransferase family that re...  Read full blog post.

DNMT's: An Overview of 3 DNA Methyltransferases
DNA methyltransferases catalyze the transfer of the methyl group from S-andenosyl methionine (SAM) to DNA. Such methylation has wide ranging function in the cell, including organismal development and cell differentiation. In cancer, abnormal hypermeth...  Read full blog post.