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DAP Kinase 1 Antibody (NB120-10524)

DAP Kinase 1 [p Ser308] Antibody (DKPS308)

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DAP Kinase 1 [p Ser308] Antibody (DKPS308) Summary:
Species:Hu
Applications:ELISA, IP, WB
Clonality:Monoclonal
Gene:DAPK1
Purity:Immunogen affinity purified
Host:Mouse
Specificity:DAP Kinase 1 Phosphospecific (DKPS308) [Ser308]
Publications:Antibody has at least 3 Background References.
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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DAP Kinase 1 [p Ser308] Antibody (DKPS308) Details:
Clone:DKPS308
Isotype:IgG1
Immunogen:Synthetic peptide, corresponding to amino acids 303-312 (pSER308) of Human DAP Kinase 1.
Localization:Cytoplasmic
Modification:p Ser308
Species Reactivity:

Cross-reacts with Human.Not yet tested in other species.

Applications:
Uses:Dot: Use at a concentration of 1 - 2 ug/ml, Determined by immunoblotting using 293T (human embryonal kidney) cells transfected with DAPKinase expression vector.ELISA: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
Dilutions:Western Blot, ELISA, immunoprecipitation
Unit Size:0.05 ml
Concentration:2.0 mg/ml
Positive Controls:1 Positive Controls
Packaging:
Storage:Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.
Buffer:0.01M PBS [pH 7.4]
Preservative:15mM Sodium Azide
Limitations:This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Gene Symbol: DAPK1
Entrez1612 (Human)
 
Background:

DAPK1 (Death-associated protein kinase 1) is a calmodulin dependent serine/threonine serine kinase which functions as a positive mediator of gamma-interferon induced programmed cell death. DAPK1 expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlates with high rates of metastasis. The loss of DAPK expression provides a link between suppression of apoptosis and metastasis. DAPK1 is thought be involved in an early apoptotic checkpoint which eliminates premalignant cells from cancer formation. Studies in bladder cancer patients have also shown that hypermethylation of DAPK1 correlates to high recurrence rates and thus DAPK1 may be used as a prognostic marker. DAPK1 is also reportedly a molecular regulator of neuronal death in epilepsy.
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Publications (3)

DAP Kinase 1 [p Ser308] Antibody (DKPS308) Background References:

  1. Deiss LP et al. Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 TNF-alpha. EMBO J 15:3861-70 (1996).
  2. Cohen O et al. DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity. EMBO J 16:998-1008 (1997).

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