Cyclin D1 Antibody (EPR2241)

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition (1). Cyclin D1 forms a serine/threonine kinase holoenzyme complex with and functions as a regulatory subunit of CDK4 or CDK6. Cyclin D1 also phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1/S phase (2-3). Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer (4). Over-expression of cyclin D1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis (5). Cyclin D1 also associates with, and regulates the activity of transcription factors, coactivators and corepressors that govern histone acetylation and chromatin remodeling proteins (6-7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 5 of 5.

Publications using NB100-79920	Applications	Species
Umeh-Garcia M, Simion C, Ho PY et al. A Novel Bioengineered MicroRNA-127 Prodrug Suppresses The Growth And Metastatic Potential Of Triple Negative Breast Cancer Cells Cancer Res. 2019-11-06 [PMID: 31694904]
Krautbauer S, Neumeier M, Rein-Fischboeck L et al. Alcohol-mediated calcium signals dysregulate pro-survival Snai2/PUMA/Bcl2 networks to promote p53-mediated apoptosis in avian neural crest progenitors Birth Defects Res 2019-04-25 [PMID: 31021056]
Russo I, Del Giorno C, Giangrieco I et al. A Peptide from Kiwifruit Exerts Anti-Inflammatory Effects in Celiac Disease Mucosa J Am Coll Nutr 2019-02-22 [PMID: 30794064] (WB, Human)	WB	Human
Russo Ilaria, Carrizzo Albino, Bochicchio Sabrina et al. siRNA Delivery for Control of Cyclin D1 and E2F1 Expression in Crohn's Disease. Translational Medicine @ UniSa 2018-03-31 [PMID: 30083520] (IF/IHC, WB, Human)	IF/IHC, WB	Human
Fan Chung-Wei, Chen Chun-Yu, Chen Kuei-Tien et al. Blockade of phospholipid scramblase 1 with its N-terminal domain antibody reduces tumorigenesis of colorectal carcinomas in vitro and in vivo. J Transl Med 2012-01-01 [PMID: 23259795] (WB, Human)	WB	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Mouse	06/17/2014	View Summary Application Western Blot Sample Tested Lysate from homogenized mouse brain cells Species Mouse

Array NB100-79920

• Cyclin D1 Antibodies
• Cyclin D1 ELISA Kits
• Cyclin D1 Lysate
• Cyclin D1 Proteins