Cdk2 Antibody (NB100-92497)

Cdk2 [Thr160] Antibody

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Cdk2 [Thr160] Antibody Summary:
Species:Hu, Mu
Applications:ELISA, IHC-P, WB
Clonality:Polyclonal
Gene:CDK2
Purity:Immunogen affinity purified
Host:Rabbit
 
 
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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Cdk2 [Thr160] Antibody Details:
Isotype:IgG
Immunogen:Synthetic peptide corresponing to the residues surrounding Threonine 160 of human p-CDK2/CDC2
Modification:Thr160
Species Reactivity:

This antibody is reactive against Human, Mouse.

Applications:
Uses:Western blot analysis of p-CDK2/CDC2 (T160) antibody in extracts from A431 cell or COLO205 cell Immunohistochemistry analysis of p-CDK2/CDC2 (T160) antibody in paraffin-embedded human breast carcinoma tissue.
Dilutions:ELISA 1:5000-1:20000, Immunohistochemistry-Paraffin 1:50-1:200, Western Blot 1:500-1:1000
Unit Size:0.1 mg
Concentration:1.0 mg/ml
Packaging:
Storage:Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.
Buffer:Phosphate buffered saline, pH 7.2.
Preservative:15mM Sodium Azide
Limitations:This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Gene Symbol: CDK2
Entrez1017 (Human)
 
Background:

Cell cycle progression is dependent on the sequential activation of cyclindependent kinases (Cdks). For full activity, the cell cycle control protein Cdk2 requires phosphorylation of a conserved residue, Threonine 160, carried out by Cdk-activating kinase 1. The kinase associated phosphatase (KAP) is a human dual specificity protein phosphatase that dephosphorylates Cdk2 on Threonine 160 in a cyclin dependent manner. KAP binds to Cdk2 and dephosphorylates Threonine 160 when the associated cyclin subunit is degraded or dissociates. Fluorescence measurements show that Threonine 160 phosphorylation increases the affinity of Cdk2 for both histone substrates and ATP and decreases its affinity for ADP.

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Cdk2 [Thr160] Antibody Images (1)
Western Blot: CDK2/CDC2 Phosphospecific Antibody [NB100-92497] - Western blot (WB) analysis of p-CDK2/CDC2 (T160) antibody in extracts from A431 cells or COLO205 cells.
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Jump to: Antibody Pairs, Lysates, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies

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Cdk2 in Context


Research Areas related to Cdk2 (5):
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