CLOCK Antibody (NBP1-30326) | Novus Biologicals

CLOCK Antibody (NBP1-30326) ( 0.1 ml)

Additional Products Available View our CLOCK products. Call 303-730-1950 for recommended products	Ordering Information:
	Catalog Number	NBP1-30326 (Sample Size Available)
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anti-clock (mouse) homolog antibody, anti-hCLOCK antibody, anti-EC 2.3.1.48 antibody, anti-BHLHE8 antibody, anti-Class E basic helix-loop-helix protein 8 antibody, anti-circadian locomoter output cycles protein kaput antibody, anti-KAT13D antibody, anti-KIAA0334bHLHe8circadian locomoter output cycles kaput protein antibody, anti-clock homolog (mouse) antibody

CLOCK Antibody Summary:

Species:	Hu, Mu, Rt	Gene:	CLOCK
Applications:	WB	Purity:	Affinity purified
Clonality:	Polyclonal	Host:	Rabbit
Publications:

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Lysates	Peptides and Proteins
Primary Antibodies	RNAi
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CLOCK Antibody Details:

Immunogen:	Synthetic peptide made to a C-terminal portion of the mouse protein (within residues 805-855). [Swiss-Prot# O08785]
Localization:	Cytoplasmic and Nuclear. Shuffling between the cytoplasm and the nucleus is under circadian regulation and is BMAL1-dependent. Phosphorylated form located in the nucleus.

Species Reactivity:

Human, mouse and rat. Immunogen has 94% identity with rat. Other species have not been tested.

Applications:

Uses:	This antibody is useful for Western blot analysis where a band can be seen at 95 kDa.
Dilutions:	Western Blot 1:1000
Unit Size:	0.1 ml (also available: 0.025 ml (sample size))
Concentration:	1.0 mg/ml
Positive Controls:	1 Positive Controls
Conjugated Antibodies:	5 Conjugated Antibodies

Packaging:

Storage:	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Buffer:	PBS with 30% glycerol
Preservative:	0.1% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: CLOCK

Entrez:	9575 (Human)
Entrez:	12753 (Mouse)
Uniprot:	O15516 (Human)
Uniprot:	O08785 (Mouse)

Related Genes:

Background:

Biological timepieces called circadian clocks are responsible for the regulation of hormonal rhythms, sleep cycles and other behaviors. The superchiasmatic nucleus (SCN), which is located in the brain, was the first mammalian circadian clock to be discovered. Clock, a member of the basic-helix-loop-helix-PAS (bHLH-PAS) family of transcription factors, has also been identified as having circadian function. Mutations within the Clock gene have been shown to increase the length of the endogenous period and to cause a loss of rhythmicity of circadian oscillations. Clock contains a DNA-binding domain, a protein dimerization domain and a glutamine-rich C-terminal region, which indicates transactivation capabilities. It has been speculated that Clock may regulate circadian rhythmicity in combination with other proteins such as Per. Per is also a PAS-domain containing protein that exhibits circadian function. Highest expression of Clock is seen in the hypothalamus and the eye.

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CLOCK Antibody Images (2)

	Western Blot: CLOCK Antibody [NBP1-30326] - Western blot analysis of CLOCK in Sol8 (mouse embryo fibroblast) cell extracts using NBP1-30326.

	Western Blot: CLOCK Antibody [NBP1-30326] - Western blot analysis of CLOCK in human brain protein using NBP1-30326.