CD40L Protein

Protein Type: Biologically Active Species: Mu Applications: WB, Func, B/N	Gene: CD40LG Purity: Protein
Specificity: This product has a purity greater than 98% by SDS-PAGE gel and HPLC analyses. The Endotoxin level is less than 0.1 ng per ug (1EU/ug).
See All CD40L Products See All CD40L Related Products: Kits Lysates Peptides and Proteins Primary Antibodies RNAi

Immunogen:	MQRGDEDPQI AAHVVSEANS NAASVLQWAK KGYYTMKSNL VMLENGKQLT VKREGLYYVY TQVTFCSNRE PSSQRPFIVG LWLKPSSGSE RILLKAANTH SSSQLCEQQS VHLGGVFELQ AGASVFVNVT EASQVIHRVG FSSFGLLKL

	21947 (Mouse)
Related Genes:	CD40, TNF, CTLA4, IL4, HLA-DQA1, NOD2, LRP6, IL2, CD80, IL10, CD4, IFNG, IL6, CD86, DCX, DCN, TBX10, CD28, CD8A, TNFSF11, SELP, NFKB1, CRP, ICAM1, APC, FAS, CCL2, CSF2, TNFRSF11B, IL2RA, TNFRSF11A, IL13, MMP9, ISG20, LRRC23, HLA-E, F2R, IL5, CD83, MAPK1

CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The soluble form of CD40L is an 18kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant murine CD40L is a soluble 16.4 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.

Reactivity:	Mouse.

Uses:	This product is useful for Western Blot, Functional, blocking or Neutralizing. Biological Activity : Determined by its ability to induce TNF-alpha and MIP-1 alpha production by murine splenocytes. The expected ED50 for this effect is < 0.1 ug/ml.
Dilutions:	Blocking/Neutralizing, Functional, Western Blot

This fully active recombinant protein is expressed in E. coli and is fully functional.

Buffer:	lyophilized
Storage:	Store at -20C. Avoid freeze-thaw cycles.
Preservative:	No Preservative
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.