CD11b Antibody (NB110-89474) | Novus Biologicals

CD11b Antibody (NB110-89474) (0.025 ml)

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	Catalog Number	NB110-89474
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anti-Neutrophil adherence receptor antibody, anti-SLEB6 antibody, anti-CD11b antigen antibody, anti-MAC1A antibody, anti-neutrophil adherence receptor alpha-M subunit antibody, anti-CR-3 alpha chain antibody, anti-macrophage antigen alpha polypeptide antibody, anti-CD11 antigen-like family member B antibody, anti-integrin alpha-M antibody, anti-Leukocyte adhesion receptor MO1 antibody, anti-antigen CD11b (p170) antibody, anti-Cell surface glycoprotein MAC-1 subunit alpha antibody, anti-MO1A antibody, anti-MAC-1 antibody, anti-CR3AMGC117044 antibody, anti-CD11Bintegrin, alpha M (complement component receptor 3, alpha; also known as CD11b(p170), macrophage antigen alpha polypeptide) antibody, anti-CD11b antibody, anti-integrin, alpha M (complement component 3 receptor 3 subunit) antibody

CD11b Antibody Summary:

Species:	Hu, Mu, Rt, Bv	Gene:	ITGAM
Applications:	WB, ICC, IF, IHC-P	Purity:	Peptide affinity purified
Clonality:	Polyclonal	Host:	Rabbit
Specificity:	CD11b
Publications:	NB110-89474 has been mentioned in at least 8 Publications

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CD11b Antibody Details:

Immunogen:	A synthetic peptide made to an internal region (within residues 250-350) of the mouse CD11b protein. [Swiss-Prot# P05555]
Localization:	Monocytes and granulocytes.
Marker:	Microglia Marker

Species Reactivity:

Reacts with human, mouse, rat and bovine. 88% sequence identity with sheep protein.

Applications:

Uses:	This CD11b antibody is useful for Western blot analysis, where a band is seen ~160 kDa, Immunocytochemistry/Immunofluorescence, and IHC-paraffin embedded sections. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Dilutions:	Immunocytochemistry 1:200, Immunofluorescence 1:200, Immunohistochemistry-Paraffin 1:400, Western Blot 2 ug/ml
Unit Size:	0.025 ml (also available: 0.1 ml)
Concentration:	1.15 mg/ml
Positive Controls:	2 Positive Controls
Conjugated Antibodies:	5 Conjugated Antibodies

Packaging:

Storage:	Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Buffer:	PBS, 30% Glycerol
Preservative:	0.1% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: ITGAM

Entrez:	3684 (Human)
	16409 (Mouse)
	25021 (Rat)
Uniprot:	P05555 (Mouse)

Related Genes:

Background:

CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% of thymocytes and is commonly used as a microglial marker in nervous tissue.

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