CD11b Antibody (EPR1344) 0.1 ml Microglia Marker, Myeloid Marker

Click image to view larger
Western Blot: Integrin alpha M/CD11b Antibody (EPR1344) [NBP1-42075] - Mouse perfipheral nerve and ganglia visualized with a 1:1000 dilution. Image provided by verified customer review.
Immunohistochemistry-Paraffin: Integrin alpha M/CD11b Antibody (EPR1344) [NBP1-42075] - Human spleen tissue.
Western Blot: Integrin alpha M/CD11b Antibody (EPR1344) [NBP1-42075] - (A) THP-1 +TPA (B) TF-1 cell lysates.
Immunohistochemistry-Paraffin: Integrin alpha M/CD11b Antibody (EPR1344) [NBP1-42075] - Analysis of paraffin-embedded human tonsil tissue using anti-CD11b.
Download Datasheet
See All Related

Ordering Information: NBP1-42075

  • Catalog Number
    NBP1-42075
  • Displayed Format
    Unconjugated
  • Size(s)
    0.1 ml
  • Availability
  • Price
    Shipping
  

CD11b Antibody (EPR1344) Summary

Species Human, Mouse, Rat (Negative)
Tested Applications WB, Flow, ICC/IF, IHC, IHC-P
Clonality
Monoclonal
Host
Rabbit
Gene
ITGAM
Purity
Protein A purified
Guarantee Plus
All of our products are backed by our 100% guarantee to work for stated and predicted species and applications.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

CD11b Antibody (EPR1344) Details

Clone
EPR1344
Isotype
IgG
Marker
Microglia Marker, Myeloid Marker
Immunogen
A synthetic peptide corresponding to residues in human CD11b was used as an immunogen.

Species Reactivity

For Mouse this antibody is recommended for Western Blot only.
Reviewed Species Read 3 rated 4
using NBP1-42075 in the following species:

Applications/Dilutions

Dilutions
  • Western Blot 1:1000-5000
  • Flow Cytometry 1:100
  • Immunocytochemistry/Immunofluorescence 1:100-250
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:100-250
Application Notes
In Western blot this antibody detects a band at approximately 170 kDa.
Molecular Weight
127 kDa
Reviewed Applications
Read 3 Review rated 4
using
NBP1-42075 in the following applications:

Contact Information

Product PDFs

Frequently Purchased Together

Reviews

Average Rating: 4
Recent Reviews
WB Tested In Mouse
Reviewed On: 02/28/2014
Rated: 4

CD11b NBP1-42075
Image 1 of 3
Earn rewards points by submitting your review for CD11b Antibody (NBP1-42075)

Publications

Earn rewards if you have published using CD11b Antibody (NBP1-42075).

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS 59%, Glycerol 40%, BSA 0.05%, pH: 7.40
Unit Size
0.1 ml
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Preservative
0.01% Sodium Azide
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

Gene Symbol ITGAM
Entrez
Uniprot

Alternate Names for CD11b Antibody (EPR1344)

  • antigen CD11b (p170)
  • CD11 antigen-like family member B
  • CD11b antigen
  • CD11b
  • CD11Bintegrin, alpha M (complement component receptor 3, alpha; also known as CD11b(p170), macrophage antigen alpha polypeptide)
  • Cell surface glycoprotein MAC-1 subunit alpha
  • CR-3 alpha chain
  • CR3AMGC117044
  • Integrin alpha M
  • integrin alpha-M
  • integrin, alpha M (complement component 3 receptor 3 subunit)
  • ITGAM
  • Leukocyte adhesion receptor MO1
  • MAC-1
  • MAC1A
  • macrophage antigen alpha polypeptide
  • MO1A
  • neutrophil adherence receptor alpha-M subunit
  • Neutrophil adherence receptor
  • SLEB6
Show More

Related Products by Gene

Background

CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.

Reviews for CD11b Antibody (NBP1-42075) (3) 43

Read what people are saying who have used CD11b Antibody (NBP1-42075).

We have 3 reviews tested in 2 species: Human, Mouse.
We have 3 reviews tested in 2: Western Blot, Immunofluorescence.
Average Rating: 4
(Based on 3 reviews)

Have you used CD11b Antibody (NBP1-42075)? Submit your review and earn rewards points which can be used for merchandise & discounts.

Sort 3 reviews for CD11b Antibody (NBP1-42075) by:
Filter by Ratings
Very Good
(3)
All Ratings
Filter by Applications
WB
(2)
IF
(1)
All Applications
Filter by Species
Human
(1)
Mouse
(2)
All Species

Images Ratings Applications Species Reviewed By Date Details
Western Blot CD11b NBP1-42075
Click to Enlarge
Very Good
WB Mouse Anonymous 02/28/2014
Show

Summary

ApplicationWestern Blot
Sample TestedMouse peripheral nerve and ganglia
SpeciesMouse
LotYG0420405C

Blocking

Blocking Details5% BSA for 1 hour at room temperature

Primary Anitbody

Dilution Ratio1:1000 in 5% BSA overnight at 4 degrees C

Secondary Antibody

Secondary Manufacturer Cat#711-036-152
Secondary Concentration1:2000

Details

Detection NotesECL detection
Western Blot CD11b NBP1-42075
Click to Enlarge
Very Good
WB Mouse Anonymous 02/28/2014
Show

Summary

ApplicationWestern Blot
Sample TestedMouse sciatic nerves
SpeciesMouse
LotYG0420405C
Immunofluorescence CD11b NBP1-42075
Click to Enlarge
Very Good
IF Human Anonymous 10/03/2013
Show

Summary

ApplicationImmunofluorescence
SpeciesHuman
Special ApplicationsThe cells were washed twice in PBS and fixed for 5 min at room temperature in 4% formaldehyde in PBS (v/v). Fixed cells were incubated for 30 min with 10% bovine serum albumin (BSA) in PBS (w/v) to block unspecific bindings. After blocking, cells were incubated with primary and secondary antibodies for 60 min each at room temperature in the dark. Antibodies were diluted in immunostain enhancer (Thermo Scientific, Belgium) as follows: rabbi anti-human CD11b 1:200 (clone EPR1344; Novus Biologicals UK), goat anti-rabbit dylight 488 1:2000 (AS09 633; Agrisera, Vännas, Sweden). Nuclei were counterstained with 4’,6’-diamidino-2-phenylindole (DAPI) and cellular membranes were stained with cell mask deep red (C10046; Invitrogen, Leusden, the Netherlands).
Pub Med ID23890538
FileView PDF

Publications for CD11b Antibody (NBP1-42075) (0)

There are no publications for CD11b Antibody (NBP1-42075).
By submitting a publication earn 200 points for your submission points towards our Rewards Program.
Have you published using CD11b Antibody (NBP1-42075)? Earn rewards points which can be used for merchandise & discounts.
Points can be redeemed for discounts and gift cards:
$50/€35/£30/$50CAN Amazon Gift Card1000 Points
Items ships for Free, please disregard any shipping charges.
$50/€35/£30/$50CAN Off Purchase (credited after checkout)1000 Points
Discount is removed from total when the order is processed. The discount will not appear in your shopping cart on check out.

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

Ask a Scientist

Submit your question on below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

FAQs for CD11b (9)

  1. I am looking for a Mac-1 (microglia cell marker) antibody to do immunostaining with my mouse brain and I checked, you have a lot of antibodies for this biomarker. I don't know which one is the best to be used for immunohistology on mouse brain tissue. Could you please help with this?
    • I would recommend NB110-89474. This antibody has been published in 11 scientific articles, including several times in IHC in mouse. As long as CD11b is expressed in your sample, it should work just fine and is backed by our 100% Novus Guarantee.
  2. What types of cells can this CD11b antibody be used as a marker for?
    • A study used this CD11b antibody to stain granulocytes in mouse uterine tissue in IHC. CD11b is also expressed on other leukocytes such as monocytes, macrophages, and natural killer cells.
  3. Do you know if this CD11b antibody can be used in CD11b positive cell depletion? 
    • This particular CD11b antibody is not reccomended for depletion studies due to the preservative used; however, our CD11b antibody NBP1-06650 is offered in a preservative free format and has been validated for blocking.
  4. Looking for a bone marrow macrophage marker can you recommend a CD11b antibody for ICC?
    • I would recommend NB110-89474 which is our most popular CD11b antibody and has been validated in ICC and cited in 18 publications.
  5. We need a CD11b antibody for IHC-P on mouse tissue conjugated to FITC, do you have one that will work?
    • We have 3 CD11b antibodies for IHC-P and just one CD11 b antibody we offer conjugated to FITC, NB110-89474F.
  6. The protocol says to do enzymatic antigen retrieval before incubating with the CD11b antibody, which enzyme is used?
    • The protocol is referencting the PIER method using Proteinase K as the enzyme.
  7. I'm not sure if this will work for me, can I get a free sample of your CD11b antibody to test?
    • We don't offer free samples but we do offer this CD11b antibody in a trial size of 0.025 ml at a reduced cost, all antibodies are backed by our 100% guarantee to work in all validated species and applications on the product's web page.
  8. In the immunohistochemistry paraffin section protocol....the PBS buffer....should it be at certain pH?
    • For IHC application, different labs cites the pH of PBS buffer in the range of 7.1 - 7.6 but most commonly used pH is pH 7.4 (this is what we use in our lab). You may use this PBS (pH 7.4) for making permeablization buffer, antibody diluent buffers and for making wash buffer. For more on the protocol that we use in our lab and for IHC-P troubleshooting suggestions, you may visit: IHC-P Protocol and IHC-P Troubleshooting.
  9. I was wondering what does Format 7C mean as far as anitbodies go?
    • 7C is a fluorophore - it is useful for FLOW. The details of the fluor are (A=425, E=500)

Customers Who Viewed This Item Also Viewed...

NB200-610
Immunocytochemistry/Immunofluorescence: Integrin beta 2/CD18 Antibody (YFC118.3) [NB200-610] - A-D Confocal microscopy of IBA-1 (green staining) immunohistochemistry of RPE flatmounts (RPE autofluorescence visible as orange due to its autofluorescence in the red and green channel) from a healthy donor (A), a geographic atrophy lesion (B), and large drusen (C and D). (A, B, D): orthogonal Z-stack projection; (C): oblique Z-stack projection and dissecting microscope appearance of postmortem large drusen after removal of the overlaying retina (inset). E-G Double-labeling on the subretinal side of the retina (to avoid masking by RPE autofluorescence) of IBA-1+ (E, green fluorescence) and CD18 (F, red fluorescence; G, merge). H. Orthogonal and lateral Z-stack of a subretinal IBA-1+ (green fluorescence) MPs adjacent to the RPE (orange autofluorescence) in the vicinity of a large drusen.Flow Cytometry: Integrin beta 2/CD18 Antibody (YFC118.3) [NB200-610] - Staining of human peripheral blood granulocytes with RAT ANTI HUMAN CD18: FITC.Immunocytochemistry/Immunofluorescence: Integrin beta 2/CD18 Antibody (YFC118.3) [NB200-610] - Analysis of canine thoracic fluid samples using anti-Integrin beta 2 antibody. The antibody showing positive cell surface staining. Image from verified customer review.

Rat Monoclonal
Species Human, Canine, Guinea Pig
Applications Flow, ICC/IF, IHC...MORE

     1 Review

AF629

Goat Polyclonal
Species Human
Applications WB, Flow, InhibCellGro

3 Publications
MAB610
TNF‑ alpha  was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) stimulated with LPS and monensin using Mouse Anti-Human TNF‑ alpha  Monoclonal Antibody (Catalog # MAB610) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (yellow; Catalog # NL007) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Non-adherent Cells.Recombinant Human TNF‑ alpha  (Catalog # 210‑TA) induces cytotoxicity in the the L‑929 mouse fibroblast cell line in a dose-dependent manner (orange line). Cytotoxicity elicited by Recombinant Human TNF‑ alpha  (0.75 ng/mL) is neutral­ized (green line) by increasing concentrations of Mouse Anti-Human TNF‑ alpha  Monoclonal Antibody (Catalog # MAB610). The ND50 is typically 0.01‑0.04 µg/mL in the presence of the metabolic inhibitor actinomycin D (1 µg/mL).

Mouse Monoclonal
Species Human
Applications WB, ICC, Neut

26 Publications
MAB3595
Western blot shows lysates of human peripheral blood mononuclear cells (PBMC). PVDF Membrane was probed with 1 µg/mL of Human Integrin  alpha L/CD11a Monoclonal Antibody (Catalog # MAB3595) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for Integrin  alpha L/CD11a at approximately 150 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Mouse Monoclonal
Species Human
Applications WB, Flow

     1 Review

2 Publications
NB100-64849

Mouse Monoclonal
Species Human
Applications Flow, IHC, IHC-Fr...MORE

     1 Review

NB100-524
Western Blot: NOD2 Antibody (2D9) [NB100-524] - Western Blot Image of anti-NOD2 (2D9) Whole cell protein from THP-1 cells was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2 ug/ml anti-NOD2 in 1% milk, and detected with an anti-mouse HRP secondary antibody using chemiluminescence.Immunocytochemistry/Immunofluorescence: NOD2 Antibody (2D9) [NB100-524] - A431 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-NOD2 (2D9) NB100-524 at a 1:200 dilution overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:500 dilution. Actin was counterstained with Phalloidin 568 (Red) at a 1:200 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.Western Blot: NOD2 Antibody (2D9) [NB100-524] - Detection of NOD2 in 20ug of NOD2 transfected 293T cell lysate using NB 100-524. ECL detection in 10 seconds.

Mouse Monoclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC...MORE

     1 Review

12 Publications
NBP1-84550
Western Blot: HLA DQA1 Antibody [NBP1-84550] - Lane 1: Marker [KDa] 250, 130, 100, 70, 55, 35, 25, 15, 10. Lane 2: Human cell line Daudi.Immunocytochemistry/Immunofluorescence: HLA DQA1 Antibody [NBP1-84550] - Staining of human cell line U-251MG shows positivity in cytoplasm.Immunohistochemistry-Paraffin: HLA DQA1 Antibody [NBP1-84550] - Staining of human tonsil shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction centra.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC...MORE

BBA3
ICAM‑1/CD54 was detected in immersion fixed human umbilical vein endothelial cells (HUVECs) using Mouse Anti-HumanICAM‑1/CD54 Monoclonal Antibody (Catalog # BBA3) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (yellow; Catalog # NL007) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Mouse Monoclonal
Species Human
Applications WB, IP, AdBlk...MORE

     4 Reviews

23 Publications
NB110-97871
Immunohistochemistry: CD11c Antibody (AP-MAB0806) [NB110-97871] - Negative controlImmunohistochemistry-Paraffin: CD11c Antibody (AP-MAB0806) [NB110-97871] - Paraffin embedded mouse spleen tissue.

Armenian Hamster Monoclonal
Species Mouse
Applications Flow, IHC, IHC-P...MORE

3 Publications
NBP1-42795
Flow Cytometry: L-Selectin/CD62L Antibody (DREG56) [NBP1-42795] - Analysis using the PE/Cy7 conjugate of NBP1-42795. Staining of normal human peripheral blood cells with Anti-Human CD4 FITC and Mouse IgG1 ? Isotype Control PE-Cy7(left) or Anti-Human CD62L (L-Seletin) PE-Cy7 (right).Flow Cytometry: L-Selectin/CD62L Antibody (DREG56) [NBP1-42795] - Analysis using the DyLight 405 conjugate of NBP1-42795. Staining of L-Selectin in human PBMCs using anti-L-Selectin antibody. Image from verified customer review.Flow Cytometry: L-Selectin/CD62L Antibody (DREG56) [NBP1-42795] - Analysis using the FITC conjugate of NBP1-42795. Staining of normal human peripheral blood cells with Anti-Human CD4 APC and Mouse IgG1 K Isotype Control FITC (left) or Anti-Human CD62L (L-Selectin) FITC (right). Cells in the lymphocyte gate were used for analysis.

Mouse Monoclonal
Species Human
Applications WB, Flow, Func...MORE

MAB206
Recombinant Human IL‑6 (Catalog # 206-IL) stimulates proliferation in the T1165.85.2.1 mouse plasmacytoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL‑6 (2.5 ng/mL) is neutralized (green line) by increasing concentrations of Human/Primate IL‑6 Monoclonal Antibody (Catalog # MAB206). The ND50 is typically 0.05-0.15 µg/mL.

Mouse Monoclonal
Species Human, Primate
Applications WB, Neut

31 Publications
MAB3832

Mouse Monoclonal
Species Human
Applications WB, Flow, Neut

10 Publications
NBP1-88968
Western Blot: NDUFA2 Antibody [NBP1-88968] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11Lane 2: Human cell line RT-4Lane 3: Human cell line U-251MG spImmunohistochemistry-Paraffin: NDUFA2 Antibody [NBP1-88968] - Staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NB100-77417
Immunocytochemistry/Immunofluorescence: CD45 Antibody (30-F11) [NB100-77417] - IF on mouse liver. Image from verified customer review.Immunohistochemistry-Paraffin: CD45 Antibody (30-F11) [NB100-77417] - IHC analysis of formalin fixed and paraffin embedded section of mouse spleen using rat monoclonal CD45 antibody (clone 30-F11) at 1:50 dilution. The antibody generated an expected membrane staining in the red and white pulp spleenocytes of the tested spleen section. Flow Cytometry: CD45 Antibody (30-F11) [NB100-77417] - Analysis of CD45 (30F11) in freshly isolated mouse  (Balb C) splenocytes (1x10^6) were stained with CD45 antibody (NB100-77417) at 1:1000 dilution and detected with FITC conjugated donkey anti-rat IgG secondary (orange). Shown with rat IgG isotype control (blue).

Rat Monoclonal
Species Mouse
Applications WB, Flow, Func...MORE

     3 Reviews

12 Publications
NBP1-19371
Western Blot: CD4 Antibody [NBP1-19371] - CD4 antibody was tested in the following cell lysates: Lane 1) human spleen 2) human tonsil 3) human placenta 4) human kidney 5) human liver 6) mouse spleen 7) mouse placenta 8) rat placenta.Immunocytochemistry/Immunofluorescence: CD4 Antibody [NBP1-19371] - CD4 antibody was tested in Jurkat cells with Dylight 488 (green). Nuclei were counterstained with DAPI (blue).Immunohistochemistry-Paraffin: CD4 Antibody [NBP1-19371] - IHC analysis of a formalin fixed paraffin embedded tissue section of mouse spleen using CD4 antibody at 1:300 dilution with HRP-DAB detection and hematoxylin counterstaining. The antibody generated a strong signal in the membranes of a subset of cells in the spleen section and the staining showed punctate appearance in some cells.

Rabbit Polyclonal
Species Human, Mouse, Rat...MORE
Applications WB, Simple Western, ICC/IF...MORE

     5 Reviews

7 Publications
NBP1-49045
Immunocytochemistry: CD8 alpha Antibody (53-6.7) [NBP1-49045] - Analysis of immersion fixed splenocytes. Primary antibody was used at a dilution of 10 ug/ml and incubated for 3 hours at room temperature.Immunohistochemistry-Frozen: CD8 alpha Antibody (53-6.7) [NBP1-49045] - Analysis of CD8+ T cells in allogeneic skin grafted onto a mouse.Flow Cytometry: CD8 alpha Antibody (53-6.7) [NBP1-49045] - Analysis of lymph nodes by multiple staining.

Rat Monoclonal
Species Mouse, Rat
Applications Flow, ICC/IF, IHC...MORE

     1 Review

5 Publications
MAB417
Recombinant Mouse IL‑10 (Catalog # 417-ML) stimulates proliferation in the MC/9‑2 mouse mast cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL‑10 (2.5 ng/mL) is neutralized (green line) by increasing concen­trations of Rat Anti-Mouse IL‑10 Monoclonal Antibody (Catalog # MAB417). The ND50 is typically 0.005-0.015 µg/mL.

Rat Monoclonal
Species Mouse
Applications WB, Neut

20 Publications
MAB3815
  Western  blot shows lysates of human kidney tissue and human prostate tissue. PVDF  membrane was probed with 2 µg/mL of Mouse Anti-Human  Aminopeptidase N/CD13 Monoclonal Antibody (Catalog # MAB3815)  followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody  (Catalog # HAF018).  A specific band was detected for Aminopeptidase N/CD13 at  approximately 150 kDa (as indicated). This experiment was conducted  under reducing conditions and using Immunoblot  Buffer Group 1.    Aminopeptidase N/CD13  was detected in immersion fixed SH-SY5Y human neuroblastoma cell line using  Mouse Anti-Human Aminopeptidase N/CD13 Monoclonal Antibody (Catalog  # MAB3815) at 8 µg/mL for 3 hours at room temperature.  Cells were stained using the NorthernLights™ 557-conjugated  Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007)  and counterstained with DAPI (blue). Specific staining was localized to  cytoplasm and plasma membranes. View our protocol for Fluorescent  ICC Staining of Cells on Coverslips. Aminopeptidase N/CD13 was detected in immersion fixed paraffin-embedded sections of human liver cancer tissue using 25 µg/mL Mouse Anti-Human Aminopeptidase N/CD13 Monoclonal Antibody (Catalog # MAB3815) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Mouse Monoclonal
Species Human
Applications WB, IHC, ICC

1 Publication

Bioinformatics Tool for CD11b

Discover related pathways, diseases and genes to CD11b. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Bioinformatics Tool
Vizit™, under license from BioVista Inc.

Blogs on CD11b

Check out the latest blog posts on CD11b.
CD11b - More than a microglial marker
The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b and CD18. It also modulates the...  Read full blog post.

CD11b: Marker for a New Type of B Cell that Participates in Cell-Mediated Immunity
Think B lymphocytes just produce antibodies? Think again! Although, of course, B cells are vital for the humoral immune response, many studies in recent years have begun to uncover antibody-independent actions of B cells: regulating T cells and thus a...  Read full blog post.

Adhesion Receptor Molecule CD11b/c is the Point of Entry for many Infectious Diseases
Pathogenic microorganisms utilize a variety of cell surface receptors to gain entry into host cells and to bypass the natural defense mechanisms. One of the most prominent receptors used in this fashion is the leukocyte adhesion receptor CD11b/c. This...  Read full blog post.

CD11b/CD18 and Neutrophil-Epithelial Interactions as Targets for Anti-Inflammatory Therapies
The beta-2 integrins, a family of four cell surface transmembrane glycoproteins expressed only on leukocytes, include CD11a/CD18, CD11b/CD18, CD11c/CD18, and CD11d/CD18. They consist of a common beta subunit (CD18) and homologous alpha subunits (CD11a...  Read full blog post.

The CD11b Antibody: A Marker for Microglial Cells
Microglia are the resident macrophages of the central nervous system, and the first line of immune defense. Pioneering antibody research in the 1990's identified the Integrin beta 2 protein (also called ITGB2, complement receptor 3, CR3, CD18, and Mac...  Read full blog post.

CD11b Expression, Leukocyte Adhesion and the Innate Immune System
CD11b is an integrin family member which pairs with CD18 to form the CR3 heterodimer. CD11b is expressed on the surface of many leukocytes including monocytes, neutrophils, natural killer cells, granulocytes and macrophages, as well as on 8% of spleen...  Read full blog post.