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Bestrophin 1 Antibody (1C2)

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Product Details

Summary
Product Discontinued
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    • Catalog Number
      H00007439-M01
    • Availability
      Product Discontinued

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Bestrophin 1 Antibody (1C2) Summary

Description
Quality control test: Antibody Reactive Against Recombinant Protein.
Immunogen
VMD2 (AAH41664 361 a.a. - 460 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. LHEGLPKNHKAAKQNVRGQEDNKAWKLKAVDAFKSAPLYQRPGYYSAPQTPLSPTPMFFPLEPSAPSKLHSVTGIDTKDKSLKTVSSGAKKSFELLSESD
Specificity
VMD2 - vitelliform macular dystrophy 2 (Best disease, bestrophin)
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
BEST1
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Western Blot
Application Notes
Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.
Publications
Read Publication using
H00007439-M01 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Bestrophin 1 Antibody (1C2)

  • ARB
  • Best disease
  • BEST
  • bestrophin 1
  • bestrophin-1
  • BMD
  • TU15B
  • vitelliform macular dystrophy 2
  • Vitelliform macular dystrophy protein 2
  • VMD2RP50

Background

BEST1 belongs to the bestrophin family of anion channels, which includes BEST2 (MIM 607335), BEST3 (MIM 607337), and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Bestrophin 1 Antibody (H00007439-M01)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.


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(1)
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Secondary Antibodies

 

Isotype Controls

Additional Bestrophin 1 Products

Research Areas for Bestrophin 1 Antibody (H00007439-M01)

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Blogs on Bestrophin 1.

Check out the latest blog posts on Bestrophin 1.
Vision Infographic: Do you see how I see?
Vision involves several parts of the eye processing light which send signals to the brain via the optic nerve to process information. Learn more about the vision process and related ocular proteins in the infographic below. Novus Biological...  Read full blog post.
Bestrophin 1: Implications in Progressive Vision Loss
The human Bestrophin family has four members, Best1, Best2, Best3 and Best4. These transmembrane proteins can function as chloride channels, and can also regulate calcium channels (1). The Bestrophins all have a conserved domain which begins at the N-...  Read full blog post.
"I can see clearly now": Targeting Bestrophin 1 to treat Bestrophinopathies
Encoded by the VMD2 gene on chromosome 11q13 Bestrophin 1 is the prototypic member of the RFP family of proteins which are more commonly called "bestrophins". The protein family was originally identified in Caenorhabditis elegans based on a conserved ...  Read full blog post.

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Bioinformatics

Gene Symbol BEST1
Entrez
OMIM
Uniprot