Beclin 1 Antibody (NB500-249) | Novus Biologicals

Beclin 1 Antibody (NB500-249) (0.1 ml)

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	Catalog Number	NB500-249 (Sample Size Available)
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anti-ATG6 autophagy related 6 homolog antibody, anti-Protein GT197 antibody, anti-Coiled-coil myosin-like BCL2-interacting protein antibody, anti-GT197 antibody, anti-beclin 1 (coiled-coil, moesin-like BCL2 interacting protein) antibody, anti-beclin1 antibody, anti-VPS30 antibody, anti-beclin-1 antibody, anti-ATG6 antibody, anti-beclin 1 (coiled-coil, moesin-like BCL2-interacting protein) antibody, anti-beclin 1, autophagy related antibody

Beclin 1 Antibody Summary:

Species:	Hu, Mu	Gene:	BECN1
Applications:	WB, ICC, IF, IHC, IHC-P, IP	Purity:	Immunogen affinity purified
Clonality:	Polyclonal	Host:	Rabbit
Specificity:	This is specific to Beclin 1.
Publications:	NB500-249 has been mentioned in at least 11 Publications

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Beclin 1 Antibody Details:

Immunogen:	NB 500-249 was raised against an internal synthetic peptide to human Beclin 1, containing residues within 1-100. This sequence has 94% identity with the mouse sequence and 88% identity with the rat sequence.
Localization:	Cell Membrane, Cytoplasmic and Golgi Apparatus. Expressed in dendrites and cell bodies of cerebellar Purkinje cells

Species Reactivity:

This antibody can be used for detection of Beclin 1 in human and mouse samples.

Applications:

Uses:	Western Blot, Immunoprecipitation, Immunocytochemistry and most histochemical applications. In Western Blot, a band is seen at ~52 kDa representing Beclin 1.
Dilutions:	Immunocytochemistry 1:50-1:200, Immunofluorescence 1:50-1:200, Immunohistochemistry, Immunohistochemistry-Paraffin, immunoprecipitation, Western Blot
Unit Size:	0.1 ml (also available: 0.025 ml (sample size))
Concentration:	1.0 mg/ml
Positive Controls:	1 Positive Controls
Conjugated Antibodies:	5 Conjugated Antibodies

Packaging:

Storage:	Store short term at 4°C. Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Buffer:	PBS, 30% glycerol
Preservative:	0.05% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: BECN1

Entrez:	8678 (Human)
Entrez:	56208 (Mouse)
Uniprot:	Q14457 (Human)

Related Genes:

Background:

Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biological processes in which autophagy is important such as cell differentiation and nutritional stress responses.

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