Bad Antibody (Y208) (NB200-615)

Bad Antibody (Y208) (NB200-615) (0.1 ml)

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	Catalog Number	NB200-615
	Size(s)	0.1 ml	Price:
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anti-Bcl2-L-8 antibody, anti-BCL-X/BCL-2 binding protein antibody, anti-BBC6 antibody, anti-Bcl-XL/Bcl-2-associated death promoter antibody, anti-BCL2-binding protein antibody, anti-Bcl-2-like protein 8 antibody, anti-BCL2-binding component 6 antibody, anti-Bcl-2-binding component 6 antibody, anti-BCL2-antagonist of cell death protein antibody, anti-BBC2 antibody, anti-BCL2L8bcl2-L-8 antibody, anti-bcl2 antagonist of cell death antibody, anti-BCL2-associated agonist of cell death antibody

Bad Antibody (Y208) Summary:

Species:	Hu, Mu, Rt	Gene:	BAD
Applications:	WB, FACS, ICC, IHC-P, IP	Purity:	IgG purified
Clonality:	Monoclonal	Host:	Rabbit
Specificity:	The antibody does not cross-react with other Bcl-2 members.
Publications:	NB200-615 has been mentioned in at least 1 Publication

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Lysates	Peptides and Proteins
Primary Antibodies	RNAi
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Bad Antibody (Y208) Details:

Clone:	Y208
Isotype:	IgG
Immunogen:	A synthetic peptide corresponding to residues in the N-term of human Bad was used as immunogen.

Species Reactivity:

Reacts in Human, Mouse, Rat.

Applications:

Uses:	This product is useful for: Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry, Immunoprecipitation, Flow Cytometry. In Western blot this antibody detects a band at approximately 23kDa.
Dilutions:	Western Blot 1:1000-10000, Immunohistochemistry-Paraffin 1:100-250, Immunocytochemistry 1:250-500, Immunoprecipitation 1:100, Flow Cytometry 1:50
MW:	23 kDa
Unit Size:	0.1 ml
Concentration:	Please see the vial label for concentration.
Positive Controls:	1 Positive Controls

Packaging:

Storage:	Store at -20°C. Avoid freeze-thaw cycles.
Buffer:	56 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA
Preservative:	0.01% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: BAD

Entrez:	572 (Human)
	12015 (Mouse)
	64639 (Rat)
Uniprot:	Q92934 (Human)

Related Genes:

Background:

Bad is a pro-apoptotic member of the Bcl-2 family. Bad will bind preferentially Bcl-xL over Bcl-2 through its partial (9-16 a.a) BH3 domain. Additionally, Bad can reverse the death repressor activity of Bcl-xL but not of Bcl-2. Upon dephosphorylation, activated Bad translocates to the mitochondria and displace Bcl-2 from tBid sequestration to initiate mitochondrial dysfunction. The switching on/off of its phosphorylation by growth/survival factors regulates Bad activity.

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Bad Antibody (Y208) Images (3)

	Western Blot: Bad Antibody (Y208) [NB200-615] - Western blot analysis on Hela cell lysate using anti-Bad (N-term), dilution 1:5,000.

	Immunohistochemistry: Bad Antibody (Y208) [NB200-615] - Immunohistochemical staining of paraffin-embedded human lymphoma using a anti-Bad (N-term)

	Immunohistochemistry: Bad Antibody (Y208) [NB200-615] - Immunohistochemical staining of paraffin-embedded human lymphoma using anti-Bad (N-term)