Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
Residues 140-160 of purified human ApoE (LDLR receptor binding site).
Species Reactivity:
Human. Though not tested, it is likely to react with mouse. It does not appear to react with rat brain tissue. Other species have not been tested.
Applications:
Uses:
This antibody is useful for Western blot analysis where a band is seen at ~36 kDa, representing the ApoE protein. It is also useful for ELISA and immunohistochemistry. Though this production has not been tested, other productions of this antibody have been useful for immunoprecipitation.
Dilutions:
ELISA ,
immunohistochemistry 2 ug/ml,
Western Blot 2 ug/ml,
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Lipoproteins are responsible for carrying cholesterol and other fats through the bloodstream as little packages and are essential for the normal breakdown of these molecules. In particular, apolipoprotein E is a major component of specific lipoproteins called very low-density lipoproteins (VLDL). A major function of VLDLs is to remove excess cholesterol from the blood and carry it to the liver for processing. Maintaining normal levels of cholesterol is essential for the prevention of cardiovascular diseases, including heart attacks and strokes.
Apolipoprotein E is a type of lipoprotein. Apolipoprotein E is associated with several cardiovascular disorders. There are three isoforms (slightly different forms) of the ApoE lipoprotein. These three isoforms are known as ApoE2, E3 and E4. ApoE2 seems to be one of several genetic factors that plays a part in increased risk of heart attacks and strokes and ApoE4 is a risk factor for coronary artery disease. As well, ApoE4 has been been suggested to play a role in type 2 Alzheimer disease.