Amyloid beta precursor protein Antibody (NB100-94358)
Amyloid beta precursor protein Antibody
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Amyloid beta precursor protein Antibody Summary: | | Gene: | APP |
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| Purity: | IgG purified |
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| Host: | Rabbit |
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| | | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional Amyloid beta precursor protein Products Amyloid beta precursor protein Antibody Details: | Isotype: | IgG |
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| Immunogen: | Rabbit anti-APP (Abeta-NT) polyclonal antibody was raised against a peptide corresponding to amino acids 653 to 662 of human amyloid A4 protein precursor (APP) or 1 to 10 of the 4K Abeta peptide generated by beta- and gamma-secretases . The peptide sequences are identical to those of rabbit, pig, bovine, guinea pig, and chicken. |
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This antibody is reactive against Human, Mouse, Rat |
| Uses: | This polyclonal antibody can be used for detection of APP and amyloid-b peptide by Western blot at 1:500 to 1:1000 dilution. Murine brain lysate can be used as positive control. It is human, mouse, and rat reactive. |
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| Dilutions: | Western Blot 1:500-1:1000, |
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| Unit Size: | 0.1 mg |
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| Concentration: | Please see the vial label for concentration. |
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Packaging: | Storage: | Store at 4 °C. Do not freeze. |
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| Buffer: | Supplied in PBS |
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| Preservative: | 0.02% Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta amyloid protein precursor (APP) is cleaved by beta'secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma'secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the brains of all suffers of Alzheimer's disease.
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Images (1) Reviews (0) Related Products (25) Exploring Amyloid beta precursor protein Working with Amyloid beta precursor protein
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Working with Amyloid beta precursor protein
Amyloid beta precursor protein Antibody Images (1) Western Blot: APP Antibody [NB100-94358] - Western blot analysis of APP in human (A), mouse (B), and rat (C) brain tissue lysates with anti-APP (AB-NT) at 1:500 dilution. |
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Publications (2)Amyloid beta precursor protein Antibody Background References:- Selkoe D.J. Cell biology of the amyloid beta-protein precursor the mechanism of Alzheimer's disease. Annu Rev Cell Biol 1994;10:373-403
- Ponte P, Gonzalez-DeWhitt P, Schilling J, Miller J, Hsu D, Greenberg B, Davis K, Wallace W, Lieberburg I, Fuller F. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 1988;331:525-7.
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