Amyloid Precursor Protein Antibody (NB300-308)
Amyloid Precursor Protein Antibody
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Distributor Data...
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anti-AAA antibody, anti-PN2 antibody, anti-CVAP antibody, anti-Cerebral vascular amyloid peptide antibody, anti-APPI antibody, anti-Amyloid beta-peptide antibody, anti-Amyloid beta A4 protein precursor isoform c antibody, anti-Amyloid beta A4 protein precursor isoform b antibody, anti-Alzheimer disease antibody, anti-AD1 antibody, anti-ABPP antibody, anti-ABETA antibody, |
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Amyloid Precursor Protein Antibody Summary: | | Gene: | APP |
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| Purity: | Immunogen affinity purified |
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| Host: | Rabbit |
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| | Specificity: | Specific for ~115k APP protein. Immunolabeling of the APP protein band is completely blocked by preadsorption of the with the peptide used as antigen. |
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| Publications: | Antibody has at least 3 Background References. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional Amyloid Precursor Protein Products Amyloid Precursor Protein Antibody Details: | Immunogen: | Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH |
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| Localization: | Cell Membrane, Cytoplasmic, Endoplasmic reticulum and Golgi Apparatus |
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Rat. Expected to react based on homology: Canine, Chicken, Human, Mouse and Primate |
| Uses: | *The investigator should determine the optimal working dilution for a specific application. |
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| Dilutions: | Western Blot 1:1000 |
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| TMW: | 115 kDa |
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| Unit Size: | 0.1 ml |
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| Concentration: | Please see the vial label for concentration. |
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Packaging: | Storage: | Store at -20 °C. Avoid freeze-thaw cycles. |
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| Buffer: | 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol |
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| Preservative: | No Preservative |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD). The phosphorylation APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD.
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Images (2) Reviews (0) Related Products (23) Exploring Amyloid Precursor Protein Working with Amyloid Precursor Protein
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Jump to: Publications, Images, Ask a Question
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Working with Amyloid Precursor Protein
Amyloid Precursor Protein Antibody Images (2) Western Blot: Amyloid Precursor Protein Antibody [NB300-308] - Rat hippocampal lysate showing the specific immunolabeling of the ~115k APP protein using NB300-308. |  Western Blot: Amyloid Precursor Protein Antibody [NB300-308] - Western blot of rat hippocampal lysate showing specific immunolabeling of the ~115k APP protein. |
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Publications (3)Amyloid Precursor Protein Antibody Background References:- Liu F, Su Y, Li B, Zhou Y, Ryder J, Gonzalez-DeWhitt P, May PC, Ni B (2003) Regulation of amyloid precursor protein (APP) phosphorylation processing by p35/cdk5 p25/cdk5. FEBS Lett 547:193-196.
- Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R (2003) APP processing synaptic function. Neuron 37:925-937.
more... - o K, Iijima KI, Elliott JI, Kirino Y, Suzuki T (2001) Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J Biol Chem 276:40353-40361.
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Related ProductsPrimary Antibodies (12)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Amyloid Precursor Protein Antibody (Y188) | NB110-55461 | Hu, Mu, Rt | FACS, ICC, IHC-P, IP, WB | (2) | (4) | | | | Amyloid Precursor Protein Antibody | NBP1-61191 | Hu, Mu, Rt | ELISA, IF, IHC, WB | (3) | | | | | Amyloid Precursor Protein Antibody (1B11F3) | NBP1-47543 | Hu | ELISA, IHC-Fr, IHC-P, WB | (2) | | | | | Amyloid Precursor Protein Antibody | NBP1-46421 | Hu, Mu, Rt | IHC-Fr, IHC-P, WB | | | | | | Amyloid Precursor Protein Antibody | NB120-15273 | Hu, Mu, Rt | IHC-P | (1) | | | | | ... and 7 more. See All » |
Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Rabbit IgG Antibody [HRP] | NB730-H | Rb | ELISA, ICC, IHC-P, WB | | (5) | | | | Rabbit IgG Antibody [FITC] | NB730-F | Rb | ICC, IHC-P | | (1) | | | | Rabbit IgG Antibody [Biotin] | NB730-B | Rb | ELISA, ICC, IHC-P, WB | | | | | | Rabbit IgG, H/L Chains Antibody [DyLight 488] | NBP1-72944 | Rb | FLISA, IF, WB | (3) | | | | | Rabbit IgG Antibody [Alkaline Phosphatase] | NB730-AP | Rb | ELISA, ICC, IHC-P, WB | | (1) | | | | See All » |
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