Amyloid Precursor Protein Antibody (NB110-55461)
Amyloid Precursor Protein Antibody (Y188)
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Anti-APP antibody, anti-A4 amyloid protein antibody, Protease Nexin II antibody antibody, PREA4 antibody, PNII antibody, PN2 antibody, PN II antibody, PN 2 antibody, Peptidase nexin II antibody, Human mRNA For Amyloid A4 Precursor Of Alzheimers Disease antibody, CVAP antibody, CTFgamma antibody, Cerebal Vascular Amyloid Peptide antibody, Beta amyloid peptide antibody, APP antibody, Anti-Protease Nexin II, Anti-PREA4, anti-PN-II antibody, Anti-PNII, Anti-PN2, Anti-PN II, Anti-PN 2, Anti-Peptidase nexin II, Anti-Human mRNA For Amyloid A4 Precursor Of Alzheimers Disease, anti-CVAP antibody, Anti-CVAP, Anti-CTFgamma, anti-Cerebral vascular amyloid peptide antibody, Anti-Cerebal Vascular Amyloid Peptide, Anti-Beta amyloid peptide, anti-APPI antibody, Anti-APPI, Anti-APP, Anti-Amyloid Of Aging And Alzheimer Disease, Anti-Amyloid beta protein, Anti-Amyloid beta precursor protein, Anti-Amyloid Beta Peptide, Anti-Amyloid Beta A4 Protein Precursor Isoform C, Anti-Amyloid Beta A4 Protein Precursor Isoform B, Anti-Amyloid Beta A4 Protein Precursor Isoform A, Anti-Amyloid beta A4 protein, Anti-Amyloid beta (A4) precursor protein, Anti-Alzheimers Disease Amyloid Protein, Anti-Alzheimer disease amyloid protein antibody, Anti-Alzheimer Disease 1, Anti-AD1, Anti-AD 1, anti-ABPP antibody, Anti-ABPP, Anti-ABETA, Anti-AAA, Anti-A4 amyloid protein, Anti-A4, |
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Amyloid Precursor Protein Antibody (Y188) Summary: | | Gene: | APBB2 |
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| Purity: | IgG purified |
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| Host: | Rabbit |
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| | Specificity: | This antibody specifically recognizes APP and its isoforms. It will not recognize either of the two Amyloid Beta Protein ( ABeta4 ) variants, ABeta1 -40 or ABeta1 -42. |
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| Publications: | Antibody has at least 4 Background References. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional Amyloid Precursor Protein Products Amyloid Precursor Protein Antibody (Y188) Details: | Clone: | Y188 |
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| Isotype: | IgG |
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| Immunogen: | A synthetic peptide corresponding to residues in the NPXY motif of human APP was used as immunogen. |
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Reacts in Human, Mouse, Rat. |
| Uses: | This product is useful for: Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry, Immunoprecipitation, Flow Cytometry. In Western blot this antibody detects a band at approximately 95kDa. |
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| Dilutions: | Western Blot 1:1000-10000, Immunohistochemistry-Paraffin 1:250-500, Immunocytochemistry 1:250-500, Immunoprecipitation 1:50, Flow Cytometry 1:20 |
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| TMW: | 95 kDa |
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| Unit Size: | 0.1 ml |
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| Concentration: | Please see the vial label for concentration. |
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| Positive Controls: | 1 Positive Controls |
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Packaging: | Storage: | Store at -20 °C. Avoid freeze-thaw cycles. |
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| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol. |
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| Preservative: | 0.01% Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: Alzheimer's disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (Aâ4) protein has been found to be the principal constituent of senile plaques of AD's patients (1-2). The amyloid beta-protein precursor (APP) is proteolytically cleaved to generate the 4 kDa Aâ4 protein. Two variants of Aâ4 can be detected; Aâ1-40 'short-tailed' and Aâ1-42 'long-tailed' (3-4).
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Images (2) Reviews (0) Related Products (23) Exploring Amyloid Precursor Protein Working with Amyloid Precursor Protein
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Jump to: Publications, Images, Protocols/Procedures, Ask a Question
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Working with Amyloid Precursor Protein
Amyloid Precursor Protein Antibody (Y188) Images (2) Staining of various paraffin-embedded human tissue samples using anti-Amyloid Beta A4 precursor. (1) Human brain tissue showed positive immunohistochemical staining for Amyloid Beta A4 precursor while (2) human breast, (3) skeletal muscle and (4) liver tissues showed negative staining. Tissues were stained in parallel on the same Normal Tissue Array. |  Western Blot: Amyloid Beta A4 precursor (APP) Antibody (Y188) [NB110-55461] - Western blot analysis on Hela cell lysate using anti- Amyloid Beta A4 precusor (NB110-55461), dilution 1:20,000 |
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Publications (4)Amyloid Precursor Protein Antibody (Y188) Background References:- Vigo-Pelfrey, C., Lee, D., Keim, P., Lieberburg, I., Schenk, D. B. (1993) J. Neurochem. 61, 1965-1968
- Dovey, H. F., Suomesaari-Chrysler, S., Lieberburg, I., Sinha, S., Kiem, P. S. (1993) NeuroReport 4, 1039-1042
more... - Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B., Beyreuther, K. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 4245-4249
- Glenner, G. G., Wong, C. W. (1984) Biochem. Biophys. Res. Commun. 120, 885-890
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Related ProductsPositive ControlsPrimary Antibodies (12)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Amyloid Precursor Protein Antibody | NBP1-61191 | Hu, Mu, Rt | ELISA, IF, IHC, WB | (3) | | | | | Amyloid Precursor Protein Antibody | NB300-308 | Rt | WB | (2) | (3) | | | | Amyloid Precursor Protein Antibody (1B11F3) | NBP1-47543 | Hu | ELISA, IHC-Fr, IHC-P, WB | (2) | | | | | Amyloid Precursor Protein Antibody | NBP1-46421 | Hu, Mu, Rt | IHC-Fr, IHC-P, WB | | | | | | Amyloid Precursor Protein Antibody | NB120-15273 | Hu, Mu, Rt | IHC-P | (1) | | | | | ... and 7 more. See All » |
Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Rabbit IgG Antibody [HRP] | NB730-H | Rb | ELISA, ICC, IHC-P, WB | | (5) | | | | Rabbit IgG Antibody [FITC] | NB730-F | Rb | ICC, IHC-P | | (1) | | | | Rabbit IgG Antibody [Biotin] | NB730-B | Rb | ELISA, ICC, IHC-P, WB | | | | | | Rabbit IgG, H/L Chains Antibody [DyLight 488] | NBP1-72944 | Rb | FLISA, IF, WB | (3) | | | | | Rabbit IgG Antibody [Alkaline Phosphatase] | NB730-AP | Rb | ELISA, ICC, IHC-P, WB | | (1) | | | | See All » |
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