Activin A Receptor Type I Antibody (NB100-79865)
Activin A Receptor Type I Antibody
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anti-CVR1 antibody, anti-type II-like kinase 2 antibody, anti-type I antibody, anti-SKR1 antibody, anti-hydroxyalkyl-protein kinase antibody, anti-FOP antibody, anti-ALK2 antibody, anti-ACVRLK2 antibody, anti-ACTRI antibody, anti-activin A type I receptor antibody, anti-activin A receptor antibody, |
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Activin A Receptor Type I Antibody Summary: | | Gene: | ACVR1 |
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| Purity: | Immunogen affinity purified |
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| Host: | Goat |
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| | | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional Activin A Receptor Type I Products Activin A Receptor Type I Antibody Details: | Isotype: | IgG |
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| Immunogen: | Synthetic peptide, C-RKFKRRNQERLNPRD, representing the internal region of the sequence according to NP_001096.1 |
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| Epitope: | RKFKRRNQERLNPRD |
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| Uses: | This antibody is useful for Peptide ELISA, Immunohistochemistry and Western Blot. Approx 60kDa band observed in Human Umbilical Cord lysates (calculated MW of 57.2kDa according to NP_001096.1). Immunohistochemistry: In paraffin embedded Human Testis shows preferential staining of cytoplasm in primary spermatocytes. |
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| Dilutions: | Peptide ELISA 1:32000 |
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| Unit Size: | 0.1 mg |
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| Concentration: | 0.5 mg/ml |
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Packaging: | Storage: | Aliquot and store at -20 °C or -80 °C. Avoid freeze-thaw cycles. |
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| Buffer: | Tris-saline [pH7.3] with 0.5% BSA |
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| Preservative: | 0.02% Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
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Images (2) Reviews (0) Related Products (22) Exploring Activin A Receptor Type I Working with Activin A Receptor Type I
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Working with Activin A Receptor Type I
Activin A Receptor Type I Antibody Images (2) Immunohistochemistry: ACVR1 Antibody [NB100-79865]- (4µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. |  Western Blot: ACVR1 Antibody [NB100-79865] - NB100-79865 (0.3ug/ml) staining of Human Umbilical Cord lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. |
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Publications (1)Activin A Receptor Type I Antibody Background References:- Shore EM, Xu M, Feldman GJ, Fenstermacher DA, Cho TJ, Choi IH, Connor JM, Delai P, Glaser DL, LeMerrer M, Morhart R, Rogers JG, Smith R, Triffitt JT, Urtizberea JA, Zasloff M, Brown MA, Kaplan FS. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited sporadic fibrodysplasia ossificans progressiva. Nat Genet. 2006 May;38(5):525-7. Epub 2006 Apr 23. Erratum in: Nat Genet. 2007 Feb;39(2):276. FOP International Research Consortium
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Related ProductsPeptides and ProteinsPrimary Antibodies (18)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Activin A Receptor Type I Antibody | NBP1-50403 | Ca, Hu, Mu, Rt | ELISA, IHC-P, WB | (2) | | | | | Activin A Receptor Type I Antibody | NBP1-90255 | Hu | IF, IHC-P, WB | (1) | | | | | Activin A Receptor Type I Antibody | NBP1-33096 | Hu | IHC-P, WB | (2) | | | | | Activin A Receptor Type I Antibody | NBP1-33500 | Hu | IHC-P, WB | (2) | | | | | Activin A Receptor Type I Antibody | NBP1-62448 | Hu, Mu | IHC, WB | (1) | | | | | ... and 13 more. See All » |
RNAi (1)Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Goat IgG Antibody [FITC] | NB710-F | Gt | ICC, IHC-P | | | | | | Goat IgG Antibody [Biotin] | NB710-B | Gt | ELISA, ICC, IHC-P, WB | | | | | | Goat IgG Antibody [Alkaline Phosphatase] | NB710-AP | Gt | ELISA, ICC, IHC-P, WB | | | | | | Goat IgG Antibody [HRP] | NB710-H | Gt | ELISA, ICC, IHC-P, WB | | (4) | | | | Goat IgG Antibody [Cy3] | NB120-6949 | Gt | ELISA, FACS, ICC, IF, IHC-Fr, IHC-P | | | | | | See All » |
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