Acetylcholinesterase Antibody

Species: Hu, Bv Applications: WB, ELISA Clonality: Monoclonal	Gene: ACHE Purity: Protein A purified Host: Mouse
Specificity: Specific for brain AChE and does not recognize AChE from erythrocytes. The can thus distinguish between mammalian brain AChE and erythrocyte AChE. Weak cross-reactivity with Torpedo marmorata AChE but none with AChE from electric eel or human BtChE. Publications: Antibody has not yet been mentioned in a publication.
See All Acetylcholinesterase Products See All Acetylcholinesterase Related Products: Lysates Peptides and Proteins Primary Antibodies RNAi
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Isotype:	IgG1 Kappa
Immunogen:	C-terminal 10 residues of brain acetylcholinesterase (human and bovine), absent from the erythrocyte enzyme.
Epitope:	C-terminal 10 residues (aa 574-583) of brain acetylc holinesterase (DS-AChE and SS-AChE) (1).

Entrez:	43 (Human)
Related Genes:	BCHE, CHAT, CAT, SH2D3C, CRAT, MIP, TRPV6, GLYAT, NGF, SPP1, TH, TAC1, APP, QPCT, G4, CHRNA2, VIP, NPY, NT5E, AFP, CSF2, H2-AB1, LAMC2, PNPLA6, GLUL, ACE, GSTA4, SST, SOD1, DLD, SLCO6A1, GSTK1, MGST1, DBH, CA1, ERMAP, CPAMD8, CAR1, ALB, GSR

Acetylcholinesterase (AChE, EC.3.1.1.7.) is an enzyme located in the postsynaptic membrane and in the muscle endplates, where it hydrolyses the neurotransmitter acetylcholin. AChE from brain is a tetramer (G4-AChE) with a molecular mass of 320 kDa, AChE from erythrocytes is a dimer (G2-AChE) with a molecular mass of 170 kDa. Detection of higher levels of AChE in amniotic fluid can indicate fetal malformations such as neural tube defects.

Reactivity:	Human and Bovine.

Uses:	ELISA and Western Blot
Dilutions:	ELISA 1:16000, Western Blot 1:75,
Concentrations:	1.0 mg/ml

Buffer:	0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl
Storage:	Store at 4C. Do not freeze.
Preservative:	15mM Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.