Home » Acetyl-CoA Carboxylase alpha/ACACA » ACACA Antibodies » Acetyl-CoA Carboxylase alpha/ACACA Antibody (EPR4971)

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Acetyl-CoA Carboxylase alpha/ACACA Antibody (EPR4971)

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Product Details

Summary
Product Discontinued
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    • Catalog Number
      NBP1-95592
    • Availability
      Product Discontinued

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Acetyl-CoA Carboxylase alpha/ACACA Antibody (EPR4971) Summary

Immunogen
A synthetic peptide corresponding to residues in N-terminus of human Acetyl CoA Carboxylase 1 (ACC1) was used as an immunogen.
Clonality
Monoclonal
Host
Rabbit
Gene
ACACA
Purity
Tissue culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:100-500
  • Immunocytochemistry/ Immunofluorescence 1:100-250
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:250-500
  • Western Blot 1:1000-10000
Theoretical MW
265 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse, Rat. Mouse cross reactivity tested by western blot and IHC. Rat cross reactivity tested by western blot only.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
49% PBS, 0.05% BSA and 50% Glycerol
Preservative
0.01% Sodium Azide
Purity
Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for Acetyl-CoA Carboxylase alpha/ACACA Antibody (EPR4971)

  • ACACA
  • ACACacetyl-CoA carboxylase 1
  • ACC1
  • ACC1ACC
  • ACCA
  • ACC-alpha
  • AcetylCoA Carboxylase alpha
  • Acetyl-CoA Carboxylase alpha
  • acetyl-Coenzyme A carboxylase alpha
  • EC 6.4.1.2

Background

Acetyl-CoA Carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for Acetyl-CoA Carboxylase alpha/ACACA Antibody (NBP1-95592). (Showing 1 - 1 of 1 FAQ).

  1. I am currently using your antibody to Acetyl-CoA Carboxylase Alpha (EPR4971; NBP1-95592), and I was wondering if you could tell me what the synthetic peptide used to generate this antibody was?
    • The immunogen for this antibody maps between amino acids 1 and 30 of human Acetyl CoA Carboxylase 1 (Swiss Prot: Q13085).

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Bioinformatics

Gene Symbol ACACA
Entrez
Uniprot