ATF4 Antibody (NB100-91671)
ATF4 Antibody
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anti-Activating Transcription Factor 4 antibody, anti-TXREB antibody, anti-TAXREB67 antibody, anti-Tax Responsive Enhancer Element B67 antibody, anti-DNA binding protein TAXREB67 antibody, anti-Cyclic AMP response element binding protein 2 antibody, anti-Cyclic AMP dependent transcription factor ATF 4 antibody, anti-CREB2 antibody, anti-CREB 2 antibody, anti-ATF4 protein antibody, anti-ATF 4 antibody |
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ATF4 Antibody Summary: | | Gene: | ATF4 |
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| Purity: | Immunogen affinity purified |
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| Host: | Rabbit |
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| | | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional ATF4 Products ATF4 Antibody Details: | Isotype: | IgG |
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| Immunogen: | Synthetic peptide corresponing to the residues surrounding Arginine 239 of human ATF4 |
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| Uses: | ELISA and Immunohistochemistry |
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| Dilutions: | ELISA 1:10000-1:20000, Immunohistochemistry-Paraffin 1:50-1:200 |
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| Unit Size: | 0.1 mg |
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| Concentration: | 1.0 mg/ml |
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Packaging: | Storage: | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
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| Buffer: | Phosphate buffered saline, pH 7.2. |
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| Preservative: | 15mM Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: Eukaryotic gene transcription is regulated by sequence-specific transcription factors that bind modular cis acting promoter and enhancer elements. The ATF/ CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The ATF/CREB family includes CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3. This family of proteins contain highly divergent N-terminal domains, but share a C-terminal leucine zipper for dimerization and DNA binding. ATF-1 is shown to play a key role in the induction of NOX1, this protein binds the cAMP response element (CRE) and mediates PKA-induced stimulation of CRE-reporter genes. ATF-2 forms homodimers and heterodimers with c-Jun to initiate CREdependent transcription. Phosphorylation of ATF-2 at Thr 69 and Thr 71 by stress-activated kinases is necessary for transcriptional activation. Myc also induces phosphorylation of ATF-2 at Thr 69 and Thr 71 to prolong the half-life of ATF-2. ATF-2 functions as a histone acetyltransferase (HAT) and acetylates Histones H2B and H4 specifically in vitro.
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Images (1) Reviews (0) Related Products (24) Exploring ATF4
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Working with ATF4
ATF4 Antibody Images (1) Immunohistochemistry-Paraffin: ATF4 Antibody [NB100-91671] - Paraffin-embedded human breast carcinoma tissue |
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