AKT1/p38 Antibody Pair

This product is produced by and distributed for Abnova, a company based in Taiwan.

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary andimmortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation israpid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that theactivation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediatorof growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independentmanner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of theapoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. (provided byRefSeq)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.