AKT1 Antibody (E45) (NB110-57279)

AKT1 Antibody (E45) (NB110-57279) ( 0.1 ml)

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	Catalog Number	NB110-57279
	Size(s)	0.1 ml	Price:
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anti-RAC-PK-alpha antibody, anti-EC 2.7.11 antibody, anti-Proto-oncogene c-Akt antibody, anti-RAC-alpha serine/threonine-protein kinase antibody, anti-Protein kinase B antibody, anti-rac protein kinase alpha antibody, anti-PRKBA antibody, anti-RAC-ALPHA antibody, anti-AKT antibody, anti-RACPKB-ALPHA antibody, anti-PKBMGC99656 antibody, anti-EC 2.7.11.1 antibody, anti-v-akt murine thymoma viral oncogene homolog 1 antibody

AKT1 Antibody (E45) Summary:

Species:	Hu, Mu, Rt	Gene:	AKT1
Applications:	WB, ICC, IHC-P, IP	Purity:	IgG purified
Clonality:	Monoclonal	Host:	Rabbit
Specificity:	The antibody can detect Akt1 and Akt3.
Publications:	NB110-57279 has at least 1 Background Reference

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Antibody Pairs	ELISA Kits
Lysates	Peptides and Proteins
Primary Antibodies	RNAi
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AKT1 Antibody (E45) Details:

Clone:	E45
Isotype:	IgG
Immunogen:	A synthetic peptide corresponding to residues surrounding Ser473 of human Akt1 was used as immunogen.

Species Reactivity:

Human, Mouse, Rat. Mouse cross reactivity tested by western blot and Immunohistochemistry. Rat cross reactivity tested by Western Blot only.

Applications:

Uses:	This product is useful for: Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry, Immunoprecipitation. In Western blot this antibody detects a band at approximately 60kDa.
Dilutions:	Western Blot 1:10000-50000, Immunohistochemistry-Paraffin 1:1000-1:2500, Immunocytochemistry 1:1000, Immunoprecipitation 1:100
Unit Size:	0.1 ml
Concentration:	Please see the vial label for concentration.

Packaging:

Storage:	Store at -20°C. Avoid freeze-thaw cycles.
Buffer:	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA.
Preservative:	0.01% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: AKT1

Entrez:	207 (Human)
	11651 (Mouse)
	24185 (Rat)
Uniprot:	P31749 (Human)

Related Genes:

Background:

Akt1/PKBalpha is a Ser/Thr protein kinase whose kinase activity plays a key role in various cellular functions, including apoptosis, glycogen synthesis, and cell growth . Akt1/PKBalpha is activated by various growth and survival factors (1). Phosphorylation on Thr308, Ser473 and Tyr474 is required for full activity. Akt1/PKBalpha inhibits apoptosis by phosphorylating and inactivating several targets, including caspase-9 (2). Akt1/PKBalpha regulates glycogen synthesis by phosphorylating and inactivating glycogen synthase kinase-3a and b (3,4). Three mammalian Akt1/PKBalpha isoforms have been identified.

Images (2)


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AKT1 Antibody (E45) Images (2)

	Western Blot: Akt1/PKBa Antibody (E45) [NB110-57279] - Analysis on NIH3T3 cell lysate using anti- Akt1 pan.

	Immunohistochemistry: Akt1/PKBa Antibody (E45) [NB110-57279] - Immunohistochemical analysis of paraffin-embedded squamous lung carcinoma using anti-Akt1/PKBa (cat. #110-57279).