The mAb 2F6 demonstrates broad species cross reactivity. It localizes ACTH in immunohistochemical techniques on formalin-fixed, paraffin-embedded or frozen sections. Source: A BALB/c mouse was immunized with ACTH synthetic peptide (1-24 fragment) conjugated KLH. Splenocytes were fused with SP-2/0.
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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ACTH occurs in cells of the anterior pituitary and in neurons in brain. It regulates the corticosteroid production in the adrenal cortex. Beta endorphin and Met enkephalin are endogenous opiates. MSH (melanocyte stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.