ABCG1 Antibody 0.1 ml

ABCG1 NB400-132

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  • All ABCG1 Products
  • 2 reviews  
  • 68 Publications
  • Alternate Names
     

Ordering Information: NB400-132

Catalog NumberNB400-132
  • FormUnconjugated
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ABCG1 Antibody Summary

 
Species Human, Mouse, Rat, Hamster
Tested Applications WB, IHC, IHC-P, In vitro
Clonality Polyclonal
Host Rabbit
Gene ABCG1
Purity Immunogen affinity purified
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ABCG1 Antibody Details

 
Immunogen A synthetic peptide made to an internal region of human ABCG1 (between residues 300-400). [UniProt# P45844]

Species Reactivity

 
Human, Mouse, Rat and Hamster.
Reviewed Species Read 2 rated 5  using NB400-132 in the following species:
 
Publications Read Publications using NB400-132 in the following species:
 

Applications/Dilutions

 
Dilutions
  • Western Blot 1:500
  • Immunohistochemistry 1:100-1:400
  • Immunohistochemistry-Paraffin 1:100-1:400
  • In vitro assay
Application Notes

This ABCG1 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry paraffin embedded sections and Western Blot. In Western blot mouse peritoneal macrophages treated with 22-R-hydroxycholesterol and T0901317 (stimulating ABCG1 expression) were tested, where a band was observed at ~90 kDa. Preliminary results suggest that this antibody does not appear to work in Immunoprecipitation.In vivo assay was reported in scientific literature.

Other Available
Formats
Alexa Fluor (R) 405 Labeled NB400-132AF405
Alexa Fluor (R) 488 Labeled NB400-132AF488
Alexa Fluor (R) 647 Labeled NB400-132AF647
Alexa Fluor (R) 700 Labeled NB400-132AF700
Biotin Labeled NB400-132B
DyLight 405 Labeled NB400-132V
DyLight 488 Labeled NB400-132G
DyLight 550 Labeled NB400-132R
DyLight 650 Labeled NB400-132C
FITC Labeled NB400-132F
HRP Labeled NB400-132H
Learn about Custom Antibody Labeling
Control Peptide
ABCG1 Peptide (NB400-132PEP)
Reviewed Applications
Read 2 reviews rated 5  using
NB400-132 in the following applications:
Publications
Read publications using
NB400-132 in the following applications:

Product PDFs

Reviews

Average Rating: 5 
Recent Reviews

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Publications

ABCG1 Antibody (NB400-132) has been mentioned in at least 68 publications.
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Protocols and FAQs

Controls & Support Products

Research Tools

View all ABCG1 Research Tools.

Packaging, Storage & Formulations

 
Storage Store at 4C. Do not freeze.
Buffer Tris-citrate/phosphate, pH 7-8
Unit Size 0.1 ml (also available in 0.025 ml (sample size))
Concentration 1 mg/ml
Preservative 0.1% Sodium Azide
Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

 
Gene Symbol ABCG1
Entrez
Uniprot

Alternate Names for ABCG1

 
  • White protein homolog
  • MGC34313
  • WHT1
  • WHITE1
  • homolog of Drosophila white
  • ATP-binding cassette transporter 8
  • white protein homolog (ATP-binding cassette transporter 8), 10ATP-binding cassette transporter member 1 of subfamily G
  • ABC8ATP-binding cassette sub-family G member 1
  • ABC transporter 8
  • ATP-binding cassette, sub-family G (WHITE), member 1

Related Products by Gene

Background

 
ABCG1 (ATP-binding cassette sub-family G member 1), a transporter protein primarily involved in macrophage lipid homeostasis, localizes to intracellular compartments associated with ER /Golgi membranes, and its expression is highest in macrophage-rich tissue such as spleen, lung, and thymus as well as in brain. ABCG1 form heterodimers with heterologous ABCG partners and functional heterodimerization with ABCG4 has been of great interest because brain cells, mainly neurons and astrocytes, depict high expression of both transporters. ABCG1 involves in the export of a variety of lipids (in conjunction with ABCA1) including cholesterol and phospholipids from macrophages to HDL. Macrophage lipid export is the first step in the reverse cholesterol transport pathway that exports cholesterol from peripheral cells to circulating lipoproteins for eventual excretion via liver. Cholesterol export to lipoprotein acceptors is compromised in macrophage foam cells, one of the early hallmarks of atherosclerosis. Moreover, ABCG1 plays role in T cells/inflammation, brain lipid homeostasis and its expression increases in macrophages of Tangier disease patients.