ABCG1 Antibody Summary
||Human, Mouse, Rat, Hamster
||WB, IHC, IHC-P, In vitro
Immunogen affinity purified
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ABCG1 Antibody Details
A synthetic peptide made to an internal region of human ABCG1 (between residues 300-400). [UniProt# P45844]
Human, Mouse, Rat and Hamster.
Read 2 rated 5 using NB400-132 in the following species:
||Read Publications using NB400-132 in the following species:
- Western Blot 1:500
- Immunohistochemistry 1:100-1:400
- Immunohistochemistry-Paraffin 1:100-1:400
- In vitro assay
This ABCG1 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry paraffin embedded sections and Western Blot. In Western blot mouse peritoneal macrophages treated with 22-R-hydroxycholesterol and T0901317 (stimulating ABCG1 expression) were tested, where a band was observed at ~90 kDa. Preliminary results suggest that this antibody does not appear to work in Immunoprecipitation.In vivo assay was reported in scientific literature.
Frequently Purchased Together
WB Tested In Mouse
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Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Tris-citrate/phosphate, pH 7-8
0.1% Sodium Azide
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
Alternate Names for ABCG1 Antibody
- ABC transporter 8
- ABC8ATP-binding cassette sub-family G member 1
- ATP-binding cassette transporter 8
- ATP-binding cassette, sub-family G (WHITE), member 1
- homolog of Drosophila white
Related Products by Gene
ABCG1 (ATP-binding cassette sub-family G member 1), a transporter protein primarily involved in macrophage lipid homeostasis, localizes to intracellular compartments associated with ER /Golgi membranes, and its expression is highest in macrophage-rich tissue such as spleen, lung, and thymus as well as in brain. ABCG1 form heterodimers with heterologous ABCG partners and functional heterodimerization with ABCG4 has been of great interest because brain cells, mainly neurons and astrocytes, depict high expression of both transporters. ABCG1 involves in the export of a variety of lipids (in conjunction with ABCA1) including cholesterol and phospholipids from macrophages to HDL. Macrophage lipid export is the first step in the reverse cholesterol transport pathway that exports cholesterol from peripheral cells to circulating lipoproteins for eventual excretion via liver. Cholesterol export to lipoprotein acceptors is compromised in macrophage foam cells, one of the early hallmarks of atherosclerosis. Moreover, ABCG1 plays role in T cells/inflammation, brain lipid homeostasis and its expression increases in macrophages of Tangier disease patients.
Product General Protocols
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FAQs for ABCG1 (2)
- In the immunohistochemistry paraffin section protocol....the PBS buffer....should it be at certain pH?
- For IHC application, different labs cites the pH of PBS buffer in the range of 7.1 - 7.6 but most commonly used pH is pH 7.4 (this is what we use in our lab). You may use this PBS (pH 7.4) for making permeablization buffer, antibody diluent buffers and for making wash buffer. For more on the protocol that we use in our lab and for IHC-P troubleshooting suggestions, you may visit: IHC-P Protocol and IHC-P Troubleshooting.
- I was wondering what does Format 7C mean as far as anitbodies go?
- 7C is a fluorophore - it is useful for FLOW. The details of the fluor are (A=425, E=500)
Bioinformatics Tool for ABCG1
Discover related pathways, diseases and genes to ABCG1. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.
Diseases for ABCG1
Discover more about diseases related to ABCG1.
Pathways for ABCG1
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Research Areas for ABCG1
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PTMs for ABCG1
Learn more about PTMs related to ABCG1.
Blogs on ABCG1
Check out the latest blog posts on ABCG1.
ABCA1 - The Caretaker for Cholesterol Transportation
The ATP-binding cassette transporter A1 (ABCA1) protein is a key gatekeeper for regulating intracellular cholesterol transport. It is one member of a large family of genes comprised of cAMP-dependent anion transporter cell membrane proteins. These imp... Read full blog post.
ABCG1: Easy as 123
ABCG1 (ATP-binding cassette sub-family G member 1) is a transporter protein that is primarily involved in macrophage lipid homeostasis. It is a member of the superfamily of ATP-binding cassette (ABC) transporters and localizes to intracellular compart... Read full blog post.
ABCG2: A Tumor Protector
ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily. Among ABC transporters ABCG2 is particularly interesting for its potential role in protecting cancer stem cells and its complex oligomeric structure (1). The ABC transporters... Read full blog post.