ABCA1 Antibody (HJ1) - Astrocyte Marker (NB100-2068)

ABCA1 Antibody (HJ1) - Astrocyte Marker (NB100-2068) (0.1 ml)

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	Catalog Number	NB100-2068 (Sample Size Available)
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anti-MGC164864 antibody, anti-EC 3.6.3.41 antibody, anti-FLJ14958 antibody, anti-EC 3.6.3 antibody, anti-HDLDT1 antibody, anti-EC 2.8.1.8 antibody, anti-ATP-binding cassette transporter 1 antibody, anti-EC 2.7.7.8 antibody, anti-CERP antibody, anti-ATP-binding cassette 1 antibody, anti-ABC-1 antibody, anti-membrane-bound antibody, anti-Cholesterol efflux regulatory protein antibody, anti-ABC1ATP-binding cassette transporter A1 antibody, anti-TGDATP-binding cassette sub-family A member 1 antibody, anti-MGC165011 antibody, anti-ATP-binding cassette, sub-family A (ABC1), member 1 antibody

ABCA1 Antibody (HJ1) - Astrocyte Marker Summary:

Species:	Hu, Mu, Rt	Gene:	ABCA1
Applications:	WB, IHC-P	Purity:	Protein G purified
Clonality:	Monoclonal	Host:	Mouse
Specificity:	This is specific for ABCA1.
Publications:	NB100-2068 has been mentioned in at least 5 Publications

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ABCA1 Antibody (HJ1) - Astrocyte Marker Details:

Clone:	HJ1
Immunogen:	50 kDa N-terminal extracellular loop of ABCA1
Marker:	Astrocyte Marker

Species Reactivity:

NB 100-2068 reacts with rat, mouse, and human ABCA1. Other species have not been tested.

Applications:

Uses:	This ABCA1 antibody is useful for IHC-paraffin embedded sections and Western blot, where a band is seen ~250 kDa . Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. Optimal dilutions should be determined by the end user.
Dilutions:	Immunohistochemistry-Paraffin 1:400, Western Blot 1:2000
Unit Size:	0.1 ml (also available: 0.025 ml (sample size))
Concentration:	Please see the vial label for concentration.
Positive Controls:	2 Positive Controls
Conjugated Antibodies:	5 Conjugated Antibodies

Packaging:

Storage:	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Buffer:	PBS containing protease inhibitors
Preservative:	0.05% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: ABCA1

Entrez:	19 (Human)

Related Genes:

Background:

Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

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