ABCA1 Antibody (A00121.01) - Astrocyte Marker (NB100-1663)

ABCA1 Antibody (A00121.01) - Astrocyte Marker (NB100-1663) (0.1 mg)

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	Catalog Number	NB100-1663
	Size(s)	0.1 mg	Price:
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anti-MGC164864 antibody, anti-EC 3.6.3.41 antibody, anti-FLJ14958 antibody, anti-EC 3.6.3 antibody, anti-HDLDT1 antibody, anti-EC 2.8.1.8 antibody, anti-ATP-binding cassette transporter 1 antibody, anti-EC 2.7.7.8 antibody, anti-CERP antibody, anti-ATP-binding cassette 1 antibody, anti-ABC-1 antibody, anti-membrane-bound antibody, anti-Cholesterol efflux regulatory protein antibody, anti-ABC1ATP-binding cassette transporter A1 antibody, anti-TGDATP-binding cassette sub-family A member 1 antibody, anti-MGC165011 antibody, anti-ATP-binding cassette, sub-family A (ABC1), member 1 antibody

ABCA1 Antibody (A00121.01) - Astrocyte Marker Summary:

Species:	Hu, Mu, Ch	Gene:	ABCA1
Applications:	WB, IHC-P, PEP-ELISA	Purity:	Immunogen affinity purified
Clonality:	Monoclonal	Host:	Mouse
Specificity:	Recognize specifically ABCA1 from human, mouse, and chicken
Publications:	NB100-1663 has been mentioned in at least 5 Publications

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ABCA1 Antibody (A00121.01) - Astrocyte Marker Details:

Clone:	A00121.01
Isotype:	IgG1
Immunogen:	Recombinant fragment, corresponding to amino acids 1800-2260 of Human ABCA1 (NM_173076).
Marker:	Astrocyte Marker

Species Reactivity:

Cross-reacts with Human, Mouse and Chicken. Not yet tested in other species.

Applications:

Uses:	WB: Predicted molecular weight: 254 kDa.
Dilutions:	Immunohistochemistry-Paraffin 1:100, Peptide ELISA 1:1000, Western Blot 1:1000
MW:	254 kDa
Unit Size:	0.1 mg
Concentration:	1.0 mg/ml
Positive Controls:	1 Positive Controls

Packaging:

Storage:	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Buffer:	PBS. pH 7.4
Preservative:	0.05% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: ABCA1

Entrez:	19 (Human)
Entrez:	11303 (Mouse)
Uniprot:	Q86UK0 (Human)

Related Genes:

Background:

This membrane-associated protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.

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ABCA1 Antibody (A00121.01) - Astrocyte Marker Images (2)

	Immunohistochemistry: ABCA 1 Antibody (A00121.01) [NB100-1663] - Immunoreactivity of ABAC1 in adipose and pancreas tissue for ABCA1 protein. A. Strong immunopositivity of exocrine glandular cells of the pancreas, especially in the basal region (arrows). Interstitial microvascular cells are apparently negative. Cells within the islet were weakly positive (data not shown). B. The negative control for Panel A. Original magnifications: 330; hematoxylin counterstain.

	WB: ABCA1 Antibody (A00121.01) [NB100-1663] - WB analysis of ABCA1 induction by cholesterol (+) in human fibroblast cells from different patients (1,2,3,4). Simultaneous bloting with anti-actin antibody was used for protein loading control.