ABCA1 Antibody (5A1-1422.11)

Species: Mu Applications: FACS Clonality: Monoclonal	Gene: ABCA1 Purity: Whole antisera Host: Rat
Specificity: This is specific for ABCA1. Publications: Antibody has not yet been mentioned in a publication.
See All ABCA1 Products See All ABCA1 Related Products: Peptides and Proteins Primary Antibodies RNAi
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Clone:	5A1-1422.11
Isotype:	IgG2a Kappa
Immunogen:	Mouse ABCA1-expressing HeLa stable transfectants.
Epitope:	Extracellular determinants on ABCA1 of an unknown po sition.
Localization:	Cell Membrane

Entrez:	19 (Human)
	11303 (Mouse)
Related Genes:	APOA1, NR1H2, NR1H3, SCARB1, ABCG1, RFC1, ATP6V0A1, BCL2A1A, RFC4, TCF3, RFC2, UGT1A6, BRP1, KLRA1, ABCA4, APOE, CD36, LDLR, CETP, ABCA13, SREBF1, TNF, LCAT, APP, LPL, INS, ABCG5, PPARA, ABCG8, SREBF2, PLTP, ARG1, H2-AB1, ABCA2, TG, CD320, NR1H4, PPARG, HMGCR, CYP27A1

Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

Reactivity:	Mouse.

Uses:	NB 400-165 may be used for Flow Cytometry. NB 400-165 is not reactive in Western Blot or ELISA.
Dilutions:	flow cytometry / FACS analysis 1:1,000 to 1:30,000,
Unit Size:	0.1ml (also available: 0.025ml (sample size))
Concentrations:	32.4 mg/ml
Positive Controls:	1 positive controls

Storage:	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Preservative:	0.1% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.