spinner

Blogs

CD8 alpha - Marker for cytotoxic T lymphocytes

The T-cell co-receptor CD8 is a cell-surface glycoprotein that bridges the lipid bilayer by interacting externally with ligands, such as major histocompatibility complex (MHC) class I, as well as internally with signaling molecules such as tyrosine kinase p56 lck. CD8 associates with lck through a z ...

Read More

Lymphocyte activation gene 3 (LAG3): No lag time in immune response

The LAG3 protein belongs to the Ig superfamily and contains 4 extracellular Ig-like domains (D1-D4). This molecule plays an key role in the immune response through negative regulation of T-cell proliferation, function, and homeostasis. It is required for maximum natural and induced regulatory T-cell ...

Read More