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The transcription factor nuclear factor kappa beta (NFkB) is highly regulated by triggers such as stress, free-radicals, UV light, and hypoxia. NFkB is one of the fastest responding transcription factors in humans. The NFKB signaling pathway is essential for cancer progression because it governs many downstream molecules that control cellular growth and development. The effects of NFkB on...

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The Dnmt1 enzyme is a member of the C5-methyltransferase family responsible for repairing cytosines in double-stranded DNA (dsDNA). This enzyme uses a nucleophilic attack mechanism and is the most abundantly found mammalian DNA methyltransferase. It primarily acts upon CpG residues and prefers hemimethylated residues, but can also methylating unmethylated DNA. The cell relies upon Dnmt1...

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