58K Golgi Protein Antibody (58K-9) (NB600-412)

58K Golgi Protein Antibody (58K-9) (NB600-412) (0.1 ml)

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	Catalog Number	NB600-412 (Sample Size Available)
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58K Golgi Protein Antibody (58K-9) Summary:

Species:	Hu, Mu, Rt, Bv, Ca	Gene:	FTCD
Applications:	WB, ICC, IF, IHC-P	Purity:	Ascites
Clonality:	Monoclonal	Host:	Mouse
Specificity:	The product recognizes an epitope located on the microtubule-binding peripheral Golgi membrane 58 kDa protein.
Publications:	NB600-412 has been mentioned in at least 7 Publications

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58K Golgi Protein Antibody (58K-9) Details:

Clone:	58K-9
Isotype:	IgG1
Immunogen:	Golgi 58K protein purified from rat liver.
Localization:	Cytoplasmic and Golgi Apparatus
Marker:	Golgi Apparatus Marker

Species Reactivity:

Human, mouse, rat, canine, and bovine.

Applications:

Uses:	This 58K golgi protein antibody (58K-9) is useful for Immunocytochemistry, Immunofluorescence, Western Blot where a band can be seen at 58 kDa, and Immunohistochemistry paraffin-embedded sections. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Dilutions:	Immunocytochemistry 1:50 - 1:100, Immunofluorescence 1:100 - 1:250, Immunohistochemistry-Paraffin 1:100 - 1:200, Western Blot 1:2000 - 1:5000
Unit Size:	0.1 ml (also available: 0.025 ml (sample size))
Concentration:	This product is unpurified. Concentration is not relevant.
Positive Controls:	1 Positive Controls

Packaging:

Storage:	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Preservative:	0.1% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: FTCD

Entrez:	10841 (Human)
	14317 (Mouse)
	89833 (Rat)
Uniprot:	O95954 (Human)
	Q91XD4 (Mouse)
	O88618 (Rat)

Related Genes:

Background:

The 58K Golgi Protein is one of the most commonly used Golgi markers. It is known to associate with the PLC gamma 1-PKC epsilon complex which leads to differentiation of certain myoblasts. It also interacts with forminotransferase cyclodeaminase and Sycl1, which is important for Golgi homeostasis during neurodegenerative events. In melanoma, autophagomes generated to feed and enhance melanoma progression display a high concentration of the 58K Golgi protein, probably as a result of ER stress. In colon cancer 58K Golgi Protein co-localizes with collagen XI, and seems to be a promising marker for immunohistopathology studies of colon cancer. Finally, the 58K Golgi protein seems to interact with growth hormone in normal circumstances; however, when growth hormone is misfolded, the interaction is ablated and the Golgi apparatus can become fragmented and incapable of normal ER-Golgi trafficking.

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