53BP1 [p Ser25] Antibody (NB100-1803)

53BP1 [p Ser25] Antibody (NB100-1803) ( 0.1 ml)

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	Catalog Number	NB100-1803
	Size(s)	0.1 ml	Price:
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anti-tumor suppressor p53-binding protein 1 antibody, anti-p53-binding protein 1 antibody, anti-tumor protein 53-binding protein, 1 antibody, anti-tumor protein p53-binding protein, 1 antibody, anti-MGC138366 antibody, anti-p202 antibody, anti-p53BP1,53BP1FLJ41424 antibody, anti-tumor protein p53 binding protein 1 antibody

53BP1 [p Ser25] Antibody Summary:

Species:	Hu, Mu	Gene:	TP53BP1
Applications:	WB, FACS, IP, PLA	Purity:	Immunogen affinity purified
Clonality:	Polyclonal	Host:	Rabbit
Publications:	NB100-1803 has been mentioned in at least 4 Publications

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53BP1 [p Ser25] Antibody Details:

Isotype:	IgG
Immunogen:	Immunogen for this antibody was a phosphorylated synthetic peptide, which represented a portion of human p53 Binding Protein 1 (GeneID 7158) around serine 25 according to the numbering given in entry NP_005648.1.
Modification:	p Ser25

Species Reactivity:

Human and Mouse.

Applications:

Uses:	This antibody is useful for Western Blot, Immunoprecipitation and Flow cytometry
Dilutions:	Flow Cytometry 0.25 ug/10^6 cells in 150 ul, Immunoprecipitation 1 to 4 mcg/mg of lysate, Proximity Ligation Assay 1:1000-1:10000, Western Blot 1:1000-1:10000
Unit Size:	0.1 ml
Concentration:	0.2 mg/ml

Packaging:

Storage:	Store at 4°C. Do not freeze.
Buffer:	Tris-buffered Saline containing 0.1% BSA
Preservative:	0.09% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: TP53BP1

Entrez:	7158 (Human)
Uniprot:	Q12888 (Human)

Related Genes:

Background:

53BP1 (p53 Binding Protein 1) is an early participant in the cellular response to DNA double-strand breaks. 53BP1 functions in a redundant role in phosphorylation of the downstream checkpoint effector proteins Brca1 and Chk2 but was required for the formation of Brca1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage. Alternate names for 53BP1 include Tumor protein p53 binding protein 1 and p202.

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53BP1 [p Ser25] Antibody Images (2)

	WB: 53BP1 Phosphospecific Antibody [NB100-1803] - Detection of Phospho 53BP1 on WCL using NB100-1803. 53BP1 was IPed using a monoclonal antibody to 53BP1. The center lane represents a sample prepared by mock IP were no antibody was used.

	Flow Cytometry: 53BP1 Phosphospecific Antibody [NB100-1803] - Flow cytometric analysis of phospho 53bp1 (S25). Jurkat cells were treated with neocarzinostatin (NCS) for 1.5 hrs. 1 Million cells were fixed, permeabilized, and stained with 1.5 ug/ml antiphospho 53bp1 (S25) NB100-1803 in a 150 ul reaction. Isotype control (black), untreated (red), NCS treated (blue).

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Publications (4)

53BP1 [p Ser25] Antibody Product Specific:

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Matsuoka et al., Science 316 (5828):1160-1166, 2007.
Kang Y, Lee J-H, Hoan NN, et al. Protein phosphatase 5 regulates the function of 53BP1 after NCS-induced DNA damage. J Biol Chem 2009:M809272200.