ABCA3 Antibody

Species: Hu Applications: ELISA Clonality: Polyclonal	Gene: ABCA3 Purity: Affinity purified Host: Rabbit
Specificity: This product is specific for Human ABCA3.
See All ABCA3 Products See All ABCA3 Related Products: RNAi
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Immunogen:	This antibody is specific for the N Terminus Region of the target protein.

Entrez:	21 (Human)
Swiss Prot:	Q99758 (Human)
Related Genes:	SFTPC, SFTPB, ABCA1, UGT1A8, TCIRG1, ABCA4, ABCA2, NKX2-1, ABCC1, ABCG2, FOXA2, ABCB1, ABCA12, ABCB1B, SFTPA1, BCL11A, SFTPA2, ABCA7, LAMP3, HEATR6, ABCC6, C17ORF71, ABCC3, ABCB1A, NPSR1, FGF7, ABCC4, ABCB5, SCAP, IPO8, MSH3, FGF10, TTF1, ABCB11, PAX3, ABCC10, CST6, MDM4, MOD2, CLDN5

ABCA3 plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol. Defects in ABCA3 are the cause of pulmonary surfactant metabolism dysfunction type 3 (SMDP3) [MIM:610921]; also called pulmonary alveolar proteinosis due to ABCA3 deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

Reactivity:	Human.

Uses:

The concentration for this product is lot dependent. Check product vial for current lot concentration. Typically concentration ranges from 0.5 to 1.5 mg/ml. This antibody is useful for Western Blot. This product has been QC tested by ELISA using a recombinant protein. Why use an untested antibody? SDIX’s GAT technology means these antibodies were produced through in vivo expression of the antigen, meaning the antibodies are highly specific to the expressed protein. Applications such as IHC and WB are more likely to be successful with GAT antibodies, than with any other production process.

Dilutions:

Western Blot 1:5000-1:20000,ELISA

Manufactured by SDIX's proprietary Genomic Antibody Technology™.GAT FAQs.

Buffer:	20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Storage:	Store at -20C. Avoid freeze-thaw cycles.
Preservative:	No Preservative
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.