17-DMAG (NB110-81562)

17-DMAG

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17-DMAG Summary:

Specificity:	17-DMAG Compound
Publications:	Antibody has at least 3 Background References.

Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.

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Applications:

Uses:	Synthetic 17-DMAG Soluble in DMSO (>25mg/mL) and ethanol (10mg/mL) Purple solid
Unit Size:	1.0 mg
Concentration:	Concentration is not relevant for this product. Please see the protocols for proper use of this product.

Packaging:

Storage:	Store at -20 °C. Avoid freeze-thaw cycles.
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Background:

17-DMAG is a water soluble & cell-permeable analog of Geldanamycin and 17-AAG (1). It binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines (2), and acts as angiogenesis inhibitor (3). This Hsp90 inhibitor shows promise in preclinical models. 17-DMAG has excellent bioavailability, is widely distributed to tissues, and is quantitatively metabolized much less than is 17-AAG.

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Publications (3)

17-DMAG Background References:

Kaur G. et al.(2004) Clin. Cancer Res. 10:4813.
Gossett D.R. et al.(2005) Gynecol. Oncol. 96:381.

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Protocols

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