14-3-3 zeta Antibody

The 14-3-3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins. 14-3-3 proteins bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14-3-3 and target proteins are strongly influenced by the phosphorylation state of 14-3-3 and the target protein. 14.3.3 zeta protein is a ubiquitous and abundant in brain. 14.3.3 zeta binds primarily to Raf noncatalytic sequences without inhibiting the Ras-Raf association or Raf-catalyzed MEK phosphorylation, thus it might act as a sweeper of misfolded protein by facilitating the formation of aggregates (inclusion bodies). Hence, 14-3-3 zeta may be considered as an auxiliary therapeutic tool in the protein aggregation disorders.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NBP1-72171	Applications	Species
Luo ZJ, Zhang XF, Rapp U, Avruch J Diabetes Research Laboratory, Massachusetts General Hospital, Charlestown 02129, USA. Identification of the 14.3.3 zeta domains important for self-association and Raf binding. J Biol Chem. 270(40):23681-7. 1995-10-06 [PMID: 7559537]

Array NBP1-72171

• 14-3-3 zeta Antibodies
• 14-3-3 zeta Lysate
• 14-3-3 zeta Proteins and Enzyme