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14-3-3 sigma was identified as an epithelial cell marker. It is part of the 14-3-3 family of proteins in which seven isoforms have been identified: beta, zeta, gamma, eta, epsilon, tau, and sigma. 14-3-3 proteins function as adaptors that bind with a number of partners to mediate various signaling pathways. 14-3-3 sigma is also called stratifin or HME1 and appears to function as a tumor suppressor whose expression can be downregulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis. Alternate names for 14-3-3 sigma include epithelial marker protein 1, SFN and YWHAS.
![Western Blot 14-3-3 sigma/Stratifin Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/14-3-3_sigma_AF4424_Western_Blot_5462.jpg)
![Knockout Validated 14-3-3 sigma/Stratifin Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/1433_sigma_AF4424_Knockout_Validated_23043.jpg)
