14-3-3 eta Antibody (3G12) (NBP1-92691) (0.1 ml)

The 14-3-3 family of proteins was originally discovered as prominent protein spots on 2 dimensional gels. They are a family of 28-33kDa proteins which are often major proteins of the cytoplasm. They function as binding partners for phosphoserine and phosphthreonine sites in other proteins, though they have other binding partners which are not dependent on phosphorylation. These binding interactions are important in the regulation of molecules such as the signaling kinases in the MAP kinase pathway c-Raf and b-Raf, the proapoptotic molecules Bad and Bax and the cell cycle regulator Cdc25. There are 7 mammalian 14-3-3 proteins and they are normally expressed as homo or in some cases heterodimers. 14-3-3 eta is widely expressed and concentrated in the nervous system. The HGNC name for 14-3-3 is YWHAH, and an alternate name is tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein 1, obviously due to a role for this protein in activation of tyrosine and tryptophan hydroxylases. The 14-3-3 eta protein accumulates in the CSF of patients suffering from Creutzfeld Jacob Disease, and can be used for the diagnosis of this disease. Furthermore, this protein binds alpha-synuclein in the Lewy bodies of Parkinson's disease and has been linked to early-onset schizopherenia.